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ABS381 | Anti-GBP5 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABS381
      DescriptionAnti-GBP5 Antibody
      Alternate Names
      • Guanylate-binding protein 5
      • GBP-TA antigen
      • GTP-binding protein 5
      • GBP-5
      • Guanine nucleotide-binding protein 5
      Background InformationGBP5, also known as GBP-TA antigen, or GTP-binding protein 5, or Guanine nucleotide-binding protein 5 or GBP-5, and encoded by the gene GBP5, is a protein that plays a role in the inflammatory response to pathogens and may also play a role in apoptosis. GBP5 stimulates cryopryrin (NLRP3 protein) assembly of the intracellular inflammasome, a multiprotein oligomer consisting of caspase 1, PYCARD, NALP and sometimes caspase 5. Inflammasomes act as sensory complexes that alert the immune system to the presence of infection or tissue damage. Nucleosomes and GBP5 are expressed in myeloid cells and are a component of the innate immune system; GBP5 acts as key rheostat for activation and assembly of the inflammasomes. Additionally, GBP5 is a GTPase that homodimerizes upon GTP-binding; dimerization is required for the second hydrolysis step from GDP to GMP. GBP5 is localized to the cytoplasm and intracellular membranes via its lipid-anchor sequences.
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
      ApplicationDetect GTP binding protein using this rabbit polyclonal antibody, Anti-GBP5 Antibody validated for use in western blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: A representative lot from an independent laboratory detected GBP5 in differentiating THP-1 cells which were untreated or treated with LPS alone, or LPS/IFN-gamma (Shenoy, A. R., et al. (2012). Science. 336(6080):481-485.).
      Biological Information
      ImmunogenLinear peptide corresponding to human GBP5.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GBP5
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~67 kDa observed. A second isoform is known to exist at 55 kDa. Uncharacterized band(s) may be observed in some cell lysates.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in K562 cell lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected GBP5 in 10 µg of K562 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-GBP5 - Q2335963 Q2335963


      Reference overviewPub Med ID
      GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals.
      Shenoy, Avinash R, et al.
      Science, 336: 481-5 (2012) 2012

      Show Abstract
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