A part of MilliporeSigma

AB1572 | Anti-GABA Transporter-2 Antibody

AB1572
10 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, R IHC, WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB1572
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-GABA Transporter-2 Antibody
      Alternate Names
      • GAT-2
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified antibody. Purified in PBS with 0.1% sodium azide.
      Applications
      ApplicationThis Anti-GABA Transporter-2 Antibody is validated for use in IH, WB for the detection of GABA Transporter-2.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesImmunohistochemistry: 1:500-1:750 on 4% paraformaldehyde fixed tissue.

      It is recommended that the antibody is diluted in PBS containing 10% normal goat serum and 0.5% Triton X-100. AB1572 has been used for light microscopic studies of the rat nervous system.

      Western blot: It has been reported that this antibody works for Western blot (Conti, 1999).

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenGAT-2, C-terminus (aa 593-602)
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityGABA Transporter-2 (GAT-2), C-terminus. No cross-reactivity to the C-termini of other transmitter transporters detected.
      Species Reactivity
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLC6A13
      • GAT-2
      • GAT2
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9NSD5 # Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity).
      SIZE: 569 amino acids; 63747 Da
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Expressed strongly in the kidney and to a lesser extent in the liver and brain.
      SIMILARITY: SwissProt: Q9NSD5 ## Belongs to the sodium:neurotransmitter symporter (SNF) family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at 2-8°C for up to 12 months. Maintain reconstituted material at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-GABA TRANSPORTER-2 (GAT-2) -2698537 2698537
      RABBIT ANTI-GABA TRANSPORTER-2 (GAT-2) -2780950 2780950
      RABBIT ANTI-GABA TRANSPORTER-2 (GAT-2) POLYCLONAL ANTIBODY -
      RABBIT ANTI-GABA TRANSPORTER-2 (GAT-2) POLYCLONAL ANTIBODY - 2186340 2186340
      RABBIT ANTI-GABA TRANSPORTER-2 (GAT-2) POLYCLONAL ANTIBODY - 2196032 2196032

      References

      Reference overviewPub Med ID
      Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy.
      Calcagnotto, Maria Elisa, et al.
      J. Neurosci., 22: 7596-605 (2002) 2002

      Show Abstract
      12196583 12196583
      Multiple gamma-Aminobutyric acid plasma membrane transporters (GAT-1, GAT-2, GAT-3) in the rat retina.
      Johnson, J, et al.
      J. Comp. Neurol., 375: 212-24 (1996) 1996

      Show Abstract
      8915826 8915826

      Data Sheet

      Title
      RABBIT ANTI-GABA TRANSPORTER-2 (GAT-2)