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AB5453 | Anti-GABA A Receptor α6 Antibody

AB5453
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R IHC, WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB5453
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-GABA A Receptor α6 Antibody
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
      Applications
      ApplicationAnti-GABA A Receptor α6 Antibody detects level of GABA A Receptor α6 & has been published & validated for use in IH & WB.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot: 1:1,000

      Immunopreciptation: The antibody will immunoprecipitate 53% of all GABA A receptors in sodium dodecylsulfate extracts of rat forebrains (150 μL) using 15 μg of antibody.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenMBP fusion protein from the cytosolic loop of rat GABA A receptor alpha6 subunit.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityGABA A receptor alpha6 subunit. The apparent molecular mass of the alpha6 subunit in rat brain membrane fractions is 56-57 kDa. The antibody shows no reactivity in the forebrain of alpha6 knockout mice.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryGABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.
      Gene Symbol
      • GABRA6
      • MGC116903
      • MGC116904
      • GABA
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q16445 # GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
      SIZE: 453 amino acids; 51024 Da
      SUBUNIT: Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
      SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
      SIMILARITY: SwissProt: Q16445 ## Belongs to the ligand-gated ionic channel (TC 1.A.9) family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-GABAA RECEPTOR alpha6 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2391408 2391408
      RABBIT ANTI-GABAA RECEPTOR alpha6 -2620199 2620199
      RABBIT ANTI-GABAA RECEPTOR alpha6 -2701571 2701571
      RABBIT ANTI-GABAA RECEPTOR alpha6 -2716595 2716595

      References

      Reference overviewSpeciesPub Med ID
      Genesis of neuronal and glial progenitors in the cerebellar cortex of peripuberal and adult rabbits.
      Ponti, G; Peretto, P; Bonfanti, L
      PloS one 3 e2366 2008

      Show Abstract
      Rabbit18523645 18523645

      Data Sheet

      Title
      RABBIT ANTI-GABAA RECEPTOR alpha6 AFFINITY PURIFIED

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies