A part of MilliporeSigma

MABN492 | Anti-GABA(B)R1 Protein Antibody, clone N93A/49

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, M WB, IHC M Purified Monoclonal Antibody
      Catalogue NumberMABN492
      DescriptionAnti-GABA(B)R1 Protein Antibody, clone N93A/49
      Alternate Names
      • Gamma-aminobutyric acid type B receptor subunit 1
      • GABA-B receptor 1
      • GABA-B-R1
      • GABA-BR1
      • GABABR1
      • Gb1
      Background InformationGamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.
      Product Information
      • Rat microsomal brain tissue
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl, and 0.05% sodium azide.
      ApplicationThis GABA(B)R1 Protein antibody is validated for use in WB & IHC for the detection of the GABA(B)R1 Protein protein.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A representative lot detected GABA(B)R1 in adult rat hippocampus tissue (Prof. J. Trimmer, University of California, Davis).

      Western Blotting Analysis: A representative lot detected GABA(B)R1 in adult rat brain tissue and in WT GABA(B)R1 mice, but demonstrated a loss of signal in GABA(B)R1 knockout mice.
      Biological Information
      ImmunogenRecombinant protein corresponding to rat GABA(B)R1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody does not cross react with GABA(B)R1.
      Species Reactivity
      • Rat
      • Mouse
      Species Reactivity NoteDemonstrated to react with Rat and Mouse. Other Homologies: Human (97% sequence homology).
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Gabbr1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~115 kDa observed. Five isoforms at 112 kDa (Isoform 1E), 108 kDa (Isoform 1A), 95 kDa (Isoform 1B), 98 kDa (Isoform 1C) and 91 kDa (Isoform 1D) are known to exist. Uncharacterized bands may be observed above ~150 kDa in some tissue lysates.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat microsomal brain tissue.

      Western Blotting: 1 µg/mL of this antibody detected GABA(B)R1 in 10 µg of rat microsomal brain tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information