A part of MilliporeSigma

06-133 | Anti-Fyn Antibody

250 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Av, H, M, R IP, WB Rb Serum Polyclonal Antibody
      Catalogue Number06-133
      ReplacesMABT208; 04-353
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Fyn Antibody
      Product Information
      ApplicationThis Anti-Fyn Antibody is validated for use in IP, WB for the detection of Fyn.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenSynthetic peptide corresponding to aa 35-51 (TPQHYPSFGVTSIPNYN) of human Fyn
      Species Reactivity
      • Avian
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.
      Gene Symbol
      • FYN
      • SLK
      • MGC45350
      • SYN
      • p59-Fyn
      Purification MethodAntiserum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P06241 # Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.
      COFACTOR: Manganese.
      SIZE: 537 amino acids; 60762 Da
      SUBUNIT: Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase. Interacts with the FYN-binding protein (FYB). Interacts with phosphorylated TOM1L1. Interacts with CD79A upon activation of the B-cell antigen receptor which increases FYN activity (By similarity). Interacts with PAG1.
      SUBCELLULAR LOCATION: Cell membrane. Note=Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.
      TISSUE SPECIFICITY: Isoform 1 is highly expressed in the brain, isoform 2 is expressed in cells of hemopoietic lineages, especially T lymphocytes.
      SIMILARITY: SwissProt: P06241 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
      Molecular Weight59kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on Jurkat cell lysate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size250 µL
      Transport Information
      Supplemental Information


      Certificates of Analysis

      TitleLot Number
      Anti-Fyn - 16314 16314
      Anti-Fyn - 19409 19409
      Anti-Fyn - 31952 31952

      References | 18 Available | See All References

      Reference overviewApplicationPub Med ID
      Cholinergic signaling inhibits oxalate transport by human intestinal T84 cells.
      Hassan, HA; Cheng, M; Aronson, PS
      American journal of physiology. Cell physiology 302 C46-58 2012

      Show Abstract
      Immunoprecipitation21956166 21956166
      Flotillin-1 mediates neurite branching induced by synaptic adhesion-like molecule 4 in hippocampal neurons.
      Swanwick CC, Shapiro ME, Vicini S, Wenthold RJ
      Mol Cell Neurosci 45 213-25. Epub 2010 Jun 25. 2010

      Show Abstract
      20600927 20600927
      Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase
      He, Z., et al
      J Biol Chem, 280:2446-54 (2005) 2005

      Immunoblotting (Western)15537652 15537652
      Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis.
      Griffiths, GJ; Koh, MY; Brunton, VG; Cawthorne, C; Reeves, NA; Greaves, M; Tilby, MJ; Pearson, DG; Ottley, CJ; Workman, P; Frame, MC; Dive, C
      The Journal of biological chemistry 279 46113-21 2004

      Show Abstract
      15326164 15326164
      Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination.
      Bock, HH; Jossin, Y; Liu, P; Förster, E; May, P; Goffinet, AM; Herz, J
      The Journal of biological chemistry 278 38772-9 2003

      Show Abstract
      12882964 12882964
      Volume expansion stimulates p72(syk) and p56(lyn) in skate erythrocytes.
      Musch, M W, et al.
      J. Biol. Chem., 274: 7923-8 (1999) 1999

      Show Abstract
      Kinase Assay10075687 10075687
      Direct interaction in T-cells between thetaPKC and the tyrosine kinase p59fyn
      Ron, D., et al
      J Biol Chem, 274:19003-10 (1999) 1999

      Immunoblotting (Western)10383400 10383400
      A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth
      Wary, K. K., et al
      Cell, 94:625-34 (1998) 1998

      Immunoprecipitation9741627 9741627
      Signaling through intercellular adhesion molecule 1 (ICAM-1) in a B cell lymphoma line. The activation of Lyn tyrosine kinase and the mitogen-activated protein kinase pathway
      Holland, J. and Owens, T.
      J Biol Chem, 272:9108-12 (1997) 1997

      Immunoprecipitation9083038 9083038
      Binding of src-like kinases to the beta-subunit of the interleukin-3 receptor
      Burton, E. A., et al
      J Biol Chem, 272:16189-95 (1997) 1997

      Immunoblotting (Western)9195918 9195918

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      Included Positive Control

      Catalog Number Description  
      12-303 Jurkat Cell Lysate Show Pricing & Availability

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      Life Science Research > Antibodies and Assays > Primary Antibodies