MABE415 | Anti-FoxP2 Antibody, clone FOXP2-73A/8

MABE415
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC, IP M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABE415
      DescriptionAnti-FoxP2 Antibody, clone FOXP2-73A/8
      Alternate Names
      • Forkhead box protein P2
      • CAG repeat protein 44
      • Trinucleotide repeat-containing gene 10 protein
      Background InformationForkhead box protein P2 (FoxP2) is a multidomain transcriptional repressor that belongs to the Fox family of proteins. The FoxP2 protein contains a forkhead-box DNA-binding domain, characteristic of the FOX group of transcription factors. In addition, this protein contains a polyglutamine tract, as well as zinc finger and leucine zipper motifs. In order for FoxP2 to bind DNA, it forms homodimers and heterodimers with FoxP1 and FoxP4. The forkhead box family of proteins play an important role in immune response, organ development and the development of cancer. Functional studies in vertebrates suggest this gene plays a role in the modulation of neural plasticity. In line with these findings, mutations of FoxP2 in humans have been linked to speech and language disorders.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationDetect FOXP2 using this mouse monoclonal antibody, Anti-FoxP2 Antibody, clone FOXP2-73A/8 validated for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunoprecipitation
      Application NotesWestern Blotting Analysis: 1 µg/mL from a representative lot detected FoxP2 in 10 µg of THP-1 cell lysate.

      Immunoprecipitation Analysis (IP): A representative lot of this antibody was demonstrated to immunoprecipitate FoxP2 using growth arrested 143B cells (Gascoyne D.M., et al. (2015). PLoS One, 10(6):e0128513).

      Immunohistochemistry Analysis: A representative lot from an independent laboratory detected FoxP2 in human tonsil tissues (Campbell, A. J., et al. (2010). Br J Haematol. 149(2):221-230.).

      Immunohistochemistry Analysis: A representative lot from an independent laboratory detected FoxP2 in proliferating chondrocytes of murine E17.5 long bone (Gascoyne D.M., et al. (2015). PLoS One, 10(6):e0128513).
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the N-terminus of Human FoxP2.
      CloneFOXP2-73A/8
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes FoxP2 isoforms at 70 kDa, 48 kDa, and 40 kDa.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FOXP2
      • CAGH44
      • TNRC10
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~80 kDa observed. Uniprot describes 9 isoforms between 9-83 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected FoxP2 in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-FoxP2, clone FOXP2-73A/8 - Q2273099 Q2273099
      Anti-FoxP2, clone FOXP2-73A/8 -2736377 2736377
      Anti-FoxP2, clone FOXP2-73A/8 -2786323 2786323
      Anti-FoxP2, clone FOXP2-73A/8 -2789404 2789404

      References

      Reference overviewPub Med ID
      The Forkhead Transcription Factor FOXP2 Is Required for Regulation of p21WAF1/CIP1 in 143B Osteosarcoma Cell Growth Arrest.
      Gascoyne, DM; Spearman, H; Lyne, L; Puliyadi, R; Perez-Alcantara, M; Coulton, L; Fisher, SE; Croucher, PI; Banham, AH
      PloS one  10  e0128513  2015

      Show Abstract
      26034982 26034982
      Aberrant expression of the neuronal transcription factor FOXP2 in neoplastic plasma cells.
      Campbell, Andrew J, et al.
      Br. J. Haematol., 149: 221-30 (2010)  2010

      Show Abstract
      20096010 20096010