A part of MilliporeSigma

AB1945 | Anti-Fibronectin Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H ELISA, WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberAB1945
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Fibronectin Antibody
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in PBS with 0.1% sodium azide.
      ApplicationDetect Fibronectin using this Anti-Fibronectin Antibody validated for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 50 - 100 ng/mL

      ELISA: 1:400-1:1600

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenPurified human plasma fibronectin
      SpecificityAffinity Purified against human Fibronectin; No cross-reactivity seen in suggeted working range. Slight cross-reactivity with human Tenascin and Laminin seen at dilutions of less than 1:700 in an ELISA assay.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
      Gene Symbol
      • FN1
      • DKFZp686O13149
      • DKFZp686H0342
      • DKFZp686I1370
      • MSF
      • FN
      • CIG
      • DKFZp686F10164
      • LETS
      • FINC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P02751 # Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth (By similarity).
      SIZE: 2386 amino acids; 262607 Da
      SUBUNIT: Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1.
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
      TISSUE SPECIFICITY: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.DEVELOPMENTAL STAGE: Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age.
      PTM: Sulfated.
      SIMILARITY: SwissProt: P02751 ## Contains 12 fibronectin type-I domains. & Contains 2 fibronectin type-II domains. & Contains 16 fibronectin type-III domains.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-HUMAN FIBRONECTIN -2521455 2521455
      RABBIT ANTI-HUMAN FIBRONECTIN -2664414 2664414
      RABBIT ANTI-HUMAN FIBRONECTIN -2669910 2669910
      RABBIT ANTI-HUMAN FIBRONECTIN -2694520 2694520
      RABBIT ANTI-HUMAN FIBRONECTIN -2730855 2730855
      RABBIT ANTI-HUMAN FIBRONECTIN -2742266 2742266
      RABBIT ANTI-HUMAN FIBRONECTIN -2772666 2772666
      RABBIT ANTI-HUMAN FIBRONECTIN -2794890 2794890

      References | 12 Available | See All References

      Reference overviewApplicationSpeciesPub Med ID
      Effect of thrombin on human amnion mesenchymal cells, mouse fetal membranes, and preterm birth.
      Mogami, H; Keller, PW; Shi, H; Word, RA
      The Journal of biological chemistry 289 13295-307 2014

      Show Abstract
      24652285 24652285
      Neutrophil cathepsin G, but not elastase, induces aggregation of MCF-7 mammary carcinoma cells by a protease activity-dependent cell-oriented mechanism.
      Yui, S; Osawa, Y; Ichisugi, T; Morimoto-Kamata, R
      Mediators of inflammation 2014 971409 2014

      Show Abstract
      24803743 24803743
      Effects of thailanstatins on glucocorticoid response in trabecular meshwork and steroid-induced glaucoma.
      Jain, A; Liu, X; Wordinger, RJ; Yorio, T; Cheng, YQ; Clark, AF
      Investigative ophthalmology & visual science 54 3137-42 2013

      Show Abstract
      23548621 23548621
      Fetal fibronectin signaling induces matrix metalloproteases and cyclooxygenase-2 (COX-2) in amnion cells and preterm birth in mice.
      Mogami, H; Kishore, AH; Shi, H; Keller, PW; Akgul, Y; Word, RA
      The Journal of biological chemistry 288 1953-66 2013

      Show Abstract
      23184961 23184961
      Cellular fibronectin expression in human trabecular meshwork and induction by transforming growth factor-β2.
      Medina-Ortiz, WE; Belmares, R; Neubauer, S; Wordinger, RJ; Clark, AF
      Investigative ophthalmology & visual science 54 6779-88 2013

      Show Abstract
      Western Blotting24030464 24030464
      Smad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in mice.
      McDowell, CM; Tebow, HE; Wordinger, RJ; Clark, AF
      Experimental eye research 116 419-23 2013

      Show Abstract
      Immunohistochemistry24184030 24184030
      Spliceosome protein (SRp) regulation of glucocorticoid receptor isoforms and glucocorticoid response in human trabecular meshwork cells.
      Jain, A; Wordinger, RJ; Yorio, T; Clark, AF
      Investigative ophthalmology & visual science 53 857-66 2012

      Show Abstract
      Western BlottingHuman22205602 22205602
      Transforming growth factor-beta2 utilizes the canonical Smad-signaling pathway to regulate tissue transglutaminase expression in human trabecular meshwork cells.
      Tovar-Vidales, T; Clark, AF; Wordinger, RJ
      Experimental eye research 93 442-51 2011

      Show Abstract
      21722634 21722634
      Binding of the fibronectin-mimetic peptide, PR_b, to alpha5beta1 on pig islet cells increases fibronectin production and facilitates internalization of PR_b functionalized liposomes.
      Nicole A Atchison,Wei Fan,Klearchos K Papas,Bernhard J Hering,Michael Tsapatsis,Efrosini Kokkoli
      Langmuir : the ACS journal of surfaces and colloids 26 2010

      Show Abstract Full Text Article
      20704278 20704278
      Leptospira interrogans binds to human cell surface receptors including proteoglycans.
      Breiner, DD; Fahey, M; Salvador, R; Novakova, J; Coburn, J
      Infection and immunity 77 5528-36 2009

      Show Abstract Full Text Article
      Western Blotting19805539 19805539

      Data Sheet


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