A part of MilliporeSigma

MAB2502 | Anti-Fibrillin-1 Antibody, NT, clone 26

100 µg  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H ELISA, IP, WB, ICC M Purified Monoclonal Antibody
      Catalogue NumberMAB2502
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Fibrillin-1 Antibody, NT, clone 26
      Product Information
      PresentationLiquid at 1 mg/mL in 20 mM phosphate buffer, 250 mM NaCl, pH 7.6, containing 0.1% sodium azide.Note: Sodium azide is toxic. MSDS available upon request.
      ApplicationAnti-Fibrillin-1 Antibody, N-terminus, clone 26 detects level of Fibrillin-1 & has been published & validated for use in ELISA, IP, WB & IC.
      Key Applications
      • ELISA
      • Immunoprecipitation
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunoblotting




      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenHuman Fibrillin-1
      SpecificityMonoclonal antibody MAB2502 recognizes human Fibrillin-1. Epitope mapping studies identify the binding site of this antibody to amino-terminal end of the molecule, between amino acid residues 45 and 450. The antibody is reactive with human, chicken, and bovine Fibrillin-1.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the fibrillin family. The encoded protein is a large, extracellular matrix glycoprotein that serve as a structural component of 10-12 nm calcium-binding microfibrils. These microfibrils provide force bearing structural support in elastic and nonelastic connective tissue throughout the body. Mutations in this gene are associated with Marfan syndrome, isolated ectopia lentis, autosomal dominant Weill-Marchesani syndrome, MASS syndrome, and Shprintzen-Goldberg craniosynostosis syndrome.
      Gene Symbol
      • FBN1
      • FBN
      • MASS
      • WMS
      • MFS1
      • OCTD
      • SGS
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P35555 # Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support.
      SIZE: 2871 amino acids; 312312 Da
      SUBUNIT: Interacts with COL16A1.
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
      PTM: Forms intermolecular disulfide bonds either with other fibrillin-1 molecules or with other components of the microfibrils.
      DISEASE: SwissProt: P35555 # Defects in FBN1 are a cause of Marfan syndrome (MFS) [MIM:154700]. MFS is an autosomal dominant disorder that affects the skeletal, ocular, and cardiovascular systems. A wide variety of skeletal abnormalities occurs with MFS, including scoliosis, chest wall deformity, tall stature, abnormal joint mobility. Ectopia lentis occurs in up to about 80% of MFS patients and is almost always bilateral. The leading cause of premature death in MFS patients is progressive dilation of the aortic root and ascending aorta, causing aortic incompetence and dissection. The majority of the more than 600 mutations in FBN1 currently known are point mutations, the rest are frameshifts and splice site mutations. Marfan syndrome has been suggested in at least 2 historical figures, Abraham Lincoln and Paganini. & Defects in FBN1 are a cause of isolated ectopia lentis (EL) [MIM:129600]. The symptoms of this autosomal dominant fibrillinopathy overlap with those of Marfan syndrome, with the exclusion of the skeletal and cardiovascular manifestations. & Defects in FBN1 are the cause of autosomal dominant Weill-Marchesani syndrome (WMS) [MIM:608328]. WMS is a rare connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, and eye abnormalities including microspherophakia, ectopia lentis, severe myopia and glaucoma. & Defects in FBN1 are a cause of Shprintzen-Goldberg craniosynostosis syndrome (SGS) [MIM:182212]. SGS is one of a group of disorders characterized by typical features of the Marfan syndrome along with premature closure of the sutures of the skull, causing deformities such as oxycephaly and scaphocephaly. & Defects in FBN1 are a cause of MASS syndrome [MIM:604308]. MASS syndrome is a heritable disorder of connective tissue characterized by involvement of the mitral valve, aorta, skeleton, and skin. MASS syndrome is closely resembling both the Marfan syndrome and the Barlow syndrome. However, no dislocation of the lenses or aneurysmal changes occur in the aorta, and the mitral valve prolapse is by no means invariable.
      SIMILARITY: SwissProt: P35555 ## Belongs to the fibrillin family. & Contains 47 EGF-like domains. & Contains 7 TGFBP (TGF-beta binding protein) repeats.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number


      Reference overviewPub Med ID
      ReGeneraTing agents Matrix therapy regenerates a functional root attachment in hamsters with periodontitis.
      Lallam-Laroye C, Baroukh B, Doucet P, Barritault D, Saffar JL, Colombier ML
      Tissue engineering Part A 2011

      Show Abstract
      21548712 21548712
      Tissue engineering for full-thickness burns: a dermal substitute from bench to bedside.
      Sabrina Kellouche, Christophe Martin, Gregory Korb, Roger Rezzonico, Delphine Bouard, Marc Benbunan, Louis Dubertret, Christophe Soler, Chantal Legrand, Christine Dosquet
      Biochemical and biophysical research communications 363 472-8 2007

      Show Abstract
      17888881 17888881
      Periodontitis destructions are restored by synthetic glycosaminoglycan mimetic.
      C Lallam-Laroye, Q Escartin, A-S Zlowodzki, D Barritault, J-P Caruelle, B Baroukh, J-L Saffar, M-L Colombier
      Journal of biomedical materials research. Part A 79 675-83 2006

      Show Abstract
      16832824 16832824
      Transplantation of reconstructed human skin on nude mice: a model system to study expression of human tenascin-X and elastic fiber components.
      Manon C Zweers, Joost Schalkwijk, Toin H van Kuppevelt, Ivonne M van Vlijmen-Willems, Mieke Bergers, Claire Lethias, Evert N Lamme
      Cell and tissue research 319 279-87 2005

      Show Abstract
      15558324 15558324
      Deficiency of tenascin-X causes abnormalities in dermal elastic fiber morphology.
      Zweers, MC; van Vlijmen-Willems, IM; van Kuppevelt, TH; Mecham, RP; Steijlen, PM; Bristow, J; Schalkwijk, J
      The Journal of investigative dermatology 122 885-91 2004

      Show Abstract
      15102077 15102077
      Expression of latent TGF-beta binding proteins and association with TGF-beta 1 and fibrillin-1 following arterial injury.
      Sanjay Sinha, Anthony M Heagerty, C Adrian Shuttleworth, Cay M Kielty
      Cardiovascular research 53 971-83 2002

      Show Abstract
      11922907 11922907
      Fibrillin-1 in human cartilage: developmental expression and formation of special banded fibers.
      Keene, D R, et al.
      J. Histochem. Cytochem., 45: 1069-82 (1997) 1997

      Show Abstract
      9267468 9267468

      Data Sheet

      Anti-Fibrillin-1, N-terminus, clone 26 - Data Sheet

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