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MAB11024 | Anti-FUSE-binding protein 3 Antibody, clone 3B2.2

100 µg  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB, ICC M Purified Monoclonal Antibody
      Catalogue NumberMAB11024
      DescriptionAnti-FUSE-binding protein 3 Antibody, clone 3B2.2
      Alternate Names
      • FUSE-binding protein 3
      • far upstream element (FUSE) binding protein 3
      • far upstream element binding protein 3
      Background InformationFUSE binding protein 3, also known as far upstream element (FUSE) binding protein 3, or FBP3 is a single-stranded nucleic acid binding protein. There are three known FUSE binding proteins (FBP1, FBP2, and FBP3). All three belong to an ancient family of single-stranded DNA binding proteins. These proteins are required for regulation of the c-myc proto-oncogene and have been shown to bind to an A/T-rich element (far-ustream element) located 1.7 kb upstream of the c-myc P2 promoter. Although their primary sequences are closely related, the FBP, FBP2, and FBP3 genes are located on different chromosomes in both mice and humans. FUSE binding proteins are believed to be multifunctional. Besides regulating the transcription of c-myc (and quite likely other targets), the FBP family has been shown to bind a variety of RNAs in vitro.
      Product Information
      • HEK293 cell lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide
      ApplicationAnti-FUSE-binding protein 3 Antibody, clone 3B2.2 is a mouse monoclonal antibody for detection of FUSE-binding protein 3 also known as far upstream element (FUSE) binding protein 3 & has been validated in WB, ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: 1:500 dilution from a representative lot detected FUSE-binding protein 3 in NIH/3T3, HeLa, and A431 cells.
      Biological Information
      ImmunogenLinear peptide corresponding to human FUSE-binding protein 3.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes FUSE-binding protein 3.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FUBP3
      • FBP3
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.

      SUBCELLULAR LOCATION: Nucleus Probable.

      TISSUE SPECIFICITY: Detected in a number of cell lines.

      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.

      SEQUENCE SIMILARITIES: Contains 4 KH domains.

      SEQUENCE CAUTION: The sequence AAC50893.1 differs from that shown. Reason: Frameshift at position 18.

      The sequence AAH01325.1 differs from that shown. Reason: Frameshift at position 527.
      Molecular Weight61 kDa Observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HEK293 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected FUSE-binding protein 3 on 10 µg of HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies