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ABE1330 | Anti-FUSE-binding protein 1 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, ICC Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABE1330
      DescriptionAnti-FUSE-binding protein 1 Antibody
      Alternate Names
      • Far upstream element-binding protein 1
      • FBP
      • FUSE-binding protein 1
      • DNA helicase V
      • hDH V
      Background InformationFUSE-binding protein 1, also known as Far upstream element-binding protein 1 FBP, FUSE-binding protein 1, DNA helicase V, hDH V, and encoded by the gene name FUBP1, regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. FUSE may act both as activator and repressor of transcription. There are three known FUSE binding proteins (FBP1, FBP2, and FBP3). All three belong to an ancient family of single-stranded DNA binding proteins. These proteins are required for regulation of the c-myc proto-oncogene and have been shown to bind to an A/T-rich element (far-ustream element) located 1.7 kb upstream of the c-myc P2 promoter. Although their primary sequences are closely related, the FBP, FBP2, and FBP3 genes are located on different chromosomes in both mice and humans. FUSE binding proteins are believed to be multifunctional. Besides regulating the transcription of c-myc (and quite likely other targets), the FBP family has been shown to bind a variety of RNAs in vitro.
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationThis Anti-FUSE-binding protein 1 | ABE1330 antibody is validated for use in WB, IC for the detection of FUSE-binding protein 1 | ABE1330.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: 2.0 µg/mL from a representative lot detected FUSE-binding protein 1 in HeLa and A431 cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human FUSE-binding protein 1 near the N-terminal.
      EpitopeNear N-terminal
      ConcentrationPlease refer to lot specific datasheet.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Rat, Mouse, Primate, Feline, Horse based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FUBP1
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~76 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected FUSE-binding protein 1 in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information