AB2250 | Anti-Eph A2/A3/A4/A5 Antibody, phospho (Tyr 596/602)

AB2250
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB2250
      DescriptionAnti-Eph A2/A3/A4/A5 Antibody, phospho (Tyr 596/602)
      Alternate Names
      • Tyrosine-protein kinase receptor ECK
      • Epithelial cell kinase
      Background InformationEphrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
      References
      Product Information
      FormatAffinity Purified
      Control
      • A431 Cell lysate.
      PresentationPurified in PBS with .07% Azide and 30% Glycerol.
      Applications
      ApplicationDetect Eph A2/A3/A4/A5 using this Anti-Eph A2/A3/A4/A5 Antibody, phospho (Tyr 596/602) validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenSynthetic Linear Peptide.
      EpitopeCytoplasmic Domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityCat. # AB2250 recognizes Eph A2/A3/A4/A5, phospho (Tyr 596/602)
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. May react with mouse, rat, horse cow, chicken, monkey, dog and Xenopus based on sequence homology. Reactivity with other species has not been determined.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. [provided by RefSeq]
      Gene Symbol
      • ECK
      • EphA2
      Modifications
      • Phosphorylation
      Purification MethodImmunoAffinity Purified
      UniProt Number
      Molecular Weight~ 140 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by western blot in A431 cell lysate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C for up to 1 year from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies