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MABT117 | Anti-Endoglin (CD105) Antibody, clone 44G4

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC, IHC, IP M Purified Monoclonal Antibody
      Catalogue NumberMABT117
      DescriptionAnti-Endoglin (CD105) Antibody, clone 44G4
      Alternate Names
      • Endoglin
      • CD104
      Background InformationEndoglin (CD105) is a homodimeric integral membrane glycoprotein comprised of a 95 kDa subunit. Endoglin is a component of the TGF-β receptor system that functions as an ancillary receptor influencing binding of the Transforming Growth Factor beta (TGF-β) family of ligands to signaling receptors. Endoglin binds to TGF-β1 and TGF-β3 with high affinity, but does not bind TGF-β2. Endoglin is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta and is weakly expressed by stromalfibroblasts. Endoglin is also expressed by U937 cells and by activated macrophages. Endoglin expression is up-regulated on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation.
      Product Information
      • HUVEC cells
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-Endoglin (CD105) Antibody, clone 44G4 is an antibody against Endoglin (CD105) for use in FC, IH & IP.
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry
      • Immunoprecipitation
      Application NotesImmunohistochemistry Analysis: A representative lot was used by an independent laboratory to detect Endoglin in normal human lymph node, tonsil, spleen thrymus, liver, breast, lung, and kidney specimens (Gougos, A., and Letarte, M. (1988). J Immunol. 141(6):1925-1933).

      Immunoprecipitation Analysis: A representative lot was used by an independent laboratory to IP Endoglin from HOON, NALM-6, 3104, 3161, HL-60, U-937, EM-3 and KG-1a cells (Gougos, A., and Letarte, M. (1988). J Immunol. 141(6):1925-1933).
      Biological Information
      ImmunogenWhole HOON Pre-B Leukemic Cells
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryEndoglin is a homodimeric transmembrane glycoprotein highly expressed by endothelial cells. It is a component of the transforming growth factor beta receptor complex as it binds TGFB1 and TGFB3 with high affinity. Mutations in the endoglin gene produce hereditary hemorrhagic telangiectasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • ENG
      • END
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.

      SUBUNIT: Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGF-beta receptors I and/or II. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      Molecular Weight71 kDa calculated
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in HUVEC cells.

      Flow Cytometry Analysis: A 1:200 dilution of this antibody detected Endoglin in HUVEC cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Endoglin (CD105), clone 44G4 - 2394101 2394101
      Anti-Endoglin (CD105), clone 44G4 - 2051396 2051396
      Anti-Endoglin (CD105), clone 44G4 - NRG1897823 NRG1897823
      Anti-Endoglin (CD105), clone 44G4 -2505099 2505099
      Anti-Endoglin (CD105), clone 44G4 -2767001 2767001
      Anti-Endoglin (CD105), clone 44G4 -2800521 2800521
      Anti-Endoglin (CD105), clone 44G4_2826586 2826586


      Reference overviewPub Med ID
      Culture of human mesenchymal stem cells using a candidate pharmaceutical grade xeno-free cell culture supplement derived from industrial human plasma pools.
      Díez, JM; Bauman, E; Gajardo, R; Jorquera, JI
      Stem cell research & therapy 6 28 2015

      Show Abstract
      25889980 25889980

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      Life Science Research > Antibodies and Assays > Primary Antibodies