A part of MilliporeSigma

ABC267 | Anti-EXOSC10 Antibody

150 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABC267
      DescriptionAnti-EXOSC10 Antibody
      Alternate Names
      • Exosome component 10
      • Autoantigen PM/Scl 2
      • P100 polymyositis-scleroderma overlap syndrome-associated autoantigen
      • Polymyositis/scleroderma autoantigen 100 kDa
      • PM/Scl-100
      • Polymyositis/scleroderma autoantigen 2
      • EXOSC10
      Background InformationExosome component 10 (EXOSC10) contains 1 3'-5' exonuclease domain and 1 HRDC domain. It is strongly enriched in the nucleolus and a small amount has been found in the cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.
      Product Information
      FormatAffinity Purified
      • HeLa cell lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide and 50% glycerol.
      ApplicationDetect the EXOSC10 protein using this Anti-EXOSC10 validated for use in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot was detected EXOSC10 in human spleen tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human EXOSC10.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • EXOSC10
      • PMSCL
      • PMSCL2
      • RRP6
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~100 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected EXOSC10 in 30 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size150 µL
      Transport Information
      Supplemental Information