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MABT504 | Anti-EPS8, clone EPR6112, Rabbit Monoclonal Antibody

MABT504
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC Rb Unpurified Monoclonal Antibody
      Description
      Catalogue NumberMABT504
      DescriptionAnti-EPS8, clone EPR6112, Rabbit Monoclonal Antibody
      Alternate Names
      • Epidermal growth factor receptor kinase substrate 8
      Background InformationEPS8 (epidermal growth factor receptor kinase substrate 8), which was originally identified as a substrate for the kinase activity of EGFR, is a multifunctional protein that is known to play a role in spermatogenesis, the regulation of actin, and other cellular processes. EPS8 uses its SH3 domain to complex with Abi1 and SOS1, leading to Rac activation and subsequent actin cytoskeletal remodeling. In the same manner, it binds with RN-tre to inhibit the internalization of EGFR. EPS8 also works with Arp3 to modulate actin dynamics within the seminiferous epithelium at the apical ES and the BTB.
      References
      Product Information
      FormatUnpurified
      PresentationRabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
      Applications
      ApplicationThis Anti-EPS8, clone EPR6112, Rabbit Monoclonal Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of EPS8.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:100-250 dilution from a representative lot detected EPS8 in human kidney tissue.

      Produced in collaboration with Epitomics™
      Biological Information
      ImmunogenSynthetic peptide corresponding to the N-terminus of human EPS8.
      EpitopeN-terminus
      CloneEPR6112
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • EPS8
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~92 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa, A375, HEK293, and K562 cell lysates.

      Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected EPS8 in HeLa, A375, HEK293, and K562 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies