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ABC257 | Anti-EPHB4 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABC257
      DescriptionAnti-EPHB4 Antibody
      Alternate Names
      • Ephrin type-B receptor 4
      • Hepatoma transmembrane kinase
      • Tyrosine-protein kinase TYRO11
      Background InformationEphrin type-B receptor 4 (EPHB4) is also called Hepatoma transmembrane kinase, and Tyrosine-protein kinase TYRO11. EPHB4 is a receptor tyrosine kinase that together with EFNB2 is critical to heart morphogenesis and angiogenesis through the regulation of cell adhesion and cell migration. EPHB4 is expressed in placenta, kidney, liver, lung, pancreas, skeletal muscle, and heart, as well as primitive and myeloid hematopoietic cells.
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationDetect EphB4 using this rabbit polyclonal antibody, Anti-EPHB4 Antibody validated for use in western blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the cytoplasmic domain of human EPHB4.
      EpitopeCytoplasmic domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Species Reactivity Note Predicted to react with Mouse, Rat, and Bovine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • EPHB4
      • HTK
      • MYK1
      • TYRO11
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~120 kDa observed. The calculated molecular weight is 108 kDa, however EPHB4 has been shown as a ~120 kDa band in western blots (Lee, Y. C., et al. (2005). BMC Cancer. 5(119):1-11).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in PC3 tissue lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected EPHB4 in 10 µg of PC3 tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information