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06-102 | Anti-EGF Antibody, neutralizing

06-102
1 mg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M NEUT, WB Rb Purified Polyclonal Antibody
      Description
      Catalogue Number06-102
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-EGF Antibody, neutralizing
      References
      Product Information
      FormatPurified
      PresentationLyophilized powder
      Applications
      ApplicationAnti-EGF Antibody, neutralizing is an antibody against EGF for use in NEUT & WB.
      Key Applications
      • Neutralizing
      • Western Blotting
      Biological Information
      ImmunogenReceptor grade mouse EGF
      HostRabbit
      SpecificityEGF
      IsotypeIgG
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryEpidermal growth factor has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells of both ectodermal and mesodermal origin. The EGF precursor is believed to exist as a membrane-bound molecule which is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide.
      Gene Symbol
      • EGF
      • URG
      • urogastrone
      Purification MethodDEAE blue ion-exchange chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01133 # EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture.
      SIZE: 1207 amino acids; 133946 Da
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P01133 ## Contains 9 EGF-like domains. & Contains 9 LDL-receptor class B repeats.
      Molecular Weight6kDa (reducing conditions)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on mouse EGF under non-reducing conditions
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsLyophilized: 2 years at -20°C Rehydrated: 1 year at -20°C
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      Anti-EGF, neutralizing - 16182 16182
      Anti-EGF, neutralizing - 19444 19444
      Anti-EGF, neutralizing - 24014 24014

      References

      Reference overviewApplicationPub Med ID
      Fungiform papilla pattern: EGF regulates inter-papilla lingual epithelium and decreases papilla number by means of PI3K/Akt, MEK/ERK, and p38 MAPK signaling.
      Liu, HX; Henson, BS; Zhou, Y; D'Silva, NJ; Mistretta, CM
      Developmental dynamics : an official publication of the American Association of Anatomists 237 2378-93 2008

      Show Abstract
      18729215 18729215
      Neutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblasts.
      DiCamillo, SJ; Yang, S; Panchenko, MV; Toselli, PA; Naggar, EF; Rich, CB; Stone, PJ; Nugent, MA; Panchenko, MP
      American journal of physiology. Lung cellular and molecular physiology 291 L232-43 2006

      Show Abstract
      16473861 16473861
      Overexpression of the epidermal growth factor receptor confers migratory properties to nonmigratory postnatal neural progenitors.
      Aguirre, A; Rizvi, TA; Ratner, N; Gallo, V
      The Journal of neuroscience : the official journal of the Society for Neuroscience 25 11092-106 2005

      Show Abstract
      16319309 16319309
      Genistein alters growth factor signaling in transgenic prostate model (TRAMP).
      Jun Wang, Isam-Eldin Eltoum, Coral A Lamartiniere
      Molecular and cellular endocrinology 219 171-80 2004

      Show Abstract
      15149738 15149738
      Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts.
      DiCamillo, SJ; Carreras, I; Panchenko, MV; Stone, PJ; Nugent, MA; Foster, JA; Panchenko, MP
      The Journal of biological chemistry 277 18938-46 2002

      Show Abstract
      11889128 11889128
      Integrin-mediated migration of murine B82L fibroblasts is dependent on the expression of an intact epidermal growth factor receptor
      Li, J., et al
      J Biol Chem, 274:11209-19 (1999) 1999

      Chemotaxis10196208 10196208
      Roles of transforming growth factor-alpha and epidermal growth factor in chick limb development.
      Dealy, CN; Scranton, V; Cheng, HC
      Developmental biology 202 43-55 1998

      Show Abstract
      9758702 9758702