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MABN1106 | Anti-EEA1, clone EPR4245, Rabbit Monoclonal Antibody

100 µL  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB Rb Unpurified Monoclonal Antibody
      Catalogue NumberMABN1106
      DescriptionAnti-EEA1, clone EPR4245, Rabbit Monoclonal Antibody
      Alternate Names
      • Early endosome antigen 1
      • Endosome-associated protein p162
      • Zinc finger FYVE domain-containing protein 2
      Background InformationEarly endosome antigen 1, also known as Endosome-associated protein p162 or Zinc finger FYVE domain-containing protein 2, and encoded by the gene name EEA1 or ZFYVE2, is a 170 kDa coiled-coil protein belonging to a group of early endosomal Rab5 effector proteins. EEA1 has a putative role in the tethering/docking of endocytic vesicles prior to their fusion with early endosomes. This protein is characterized as containing a zinc finger-like domain and coiled-coil regions. The zinc finger-like domain, also known as the FYVE finger, is a motif rich in cystine, is a necessary component of EEA1’s ability for endosomal targeting, and is specifically known for its dual interaction with Rab5 GTPase and phosphotidylinositol 3-phosphate (Ptdlns-3-P).
      Product Information
      PresentationRabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
      ApplicationThis Anti-EEA1, clone EPR4245, Rabbit Monoclonal Antibody is validated for use in Western Blotting for the detection of EEA1.
      Key Applications
      • Western Blotting
      Application NotesProduced in collaboration with Epitomics™
      Biological Information
      ImmunogenSynthetic peptide corresponding to the N-terminus of human EEA1.
      ConcentrationPlease refer to lot specific datasheet.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • EEA1
      • ZFYVE2
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~170 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in COS-1, NIH/3T3 (lane 2), C6, HeLa, Jurkat, and JAR cell lysates.

      Western Blotting Analysis: A 1:10,000-50,000 dilution of this antibody detected EEA1 in COS-1, NIH/3T3 (lane 2), C6, HeLa, Jurkat, and JAR cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies