MABN463 | Anti-Dopamine D3 receptor Antibody, clone N331/19

MABN463
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, H IHC, ICC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABN463
      DescriptionAnti-Dopamine D3 receptor Antibody, clone N331/19
      Alternate Names
      • D(3) dopamine receptor
      • Dopamine D3 receptor
      Background InformationDopamine is a widely distributed neurotransmitter produced by hydroxylation of L-tyrosine, followed by decarboxylation with DOPA decarboxylase. Dopamine exerts its actions by interacting with multiple classes of dopamine receptors that belong to the family of G protein-coupled receptors. Thus far five dopamine receptor subtypes have been reported that are classified into two main families based on their sequence and similarity in signal role. The D1-like dopamine receptors include the dopamine receptors D1 and D5. Binding of dopamine to these receptors leads to the activation of adenylyl cyclase, via a Gs protein, leading to increased cAMP production. The dopamine D2-like receptor group consists of D2, D3, and D4 receptors, which are coupled to Gi/o proteins and act by inhibiting adenylyl cyclase activity. D3 receptor subtype was first cloned and characterized by Sokoloff et al in 1990 (Nature 347, pp 146-151). D3 receptor coupling to various signal transduction mechanisms usually mimic those of D2 receptors, however, their cerebral distribution is very different. Highest expression of D3 receptors is found in ventral striatum in human brain. Dopamine D3 receptor represents a potential target for development of drugs to treat various neuropsychiatric and neurological disorders such as schizophrenia, Parkinson’s disease, drugs of abuse.
      References
      Product Information
      FormatPurified
      Control
      • Rat thalamus tissue
      PresentationPurified mouse monoclonal IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis Dopamine D3 receptor antibody is validated for use in IHC & ICC for the detection of the Dopamine D3 receptor protein.
      Key Applications
      • Immunohistochemistry
      • Immunocytochemistry
      Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Dopamine D3 recpetor in rat cerebral cortex tissue.
      Biological Information
      ImmunogenRecombinant protein corresponding to human Dopamine D3 receptor.
      CloneN331/19
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Rat
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • DRD3
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight44 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in rat thalamus tissue.

      Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Dopamine D3 receptor in rat thalamus tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies