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MAB394-250UG | Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2

250 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R IL M Saporin Monoclonal Antibody
      Catalogue NumberMAB394-250UG
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2
      Product Information
      PresentationSaporin Conjugated. Sterile liquid. Provided in phosphate buffered saline. Contains no preservative.
      ApplicationAnti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2 detects level of Dopamine β Hydroxylase & has been published & validated for use in 0.
      Key Applications
      • Immunolesioning
      Application NotesImmunotoxin
      Biological Information
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityDopamine b-HydroxylaseDBH is a single gene product that exists as a cytosolic enzyme, as a membrane protein and is secreted into the circulation (Lewis & Asnani, 1992). Because of its residence time as a plasma membrane-bound protein, it is able to be used as a targeting agent for neurons. The target neurons include postganglionic sympathetic neurons and all noradrenergic and adrenergic neurons of the central nervous system. As such anti-DBH-SAP can be used for the production of acute peripheral autonomic failure in a model for the human disease. It can also be used for the analysis of the behavioral effects of noradrenergic or adrenergic ablation. When injected intraventricularly, noradrenergic neurons of the locus coeruleus are eliminated (Wiley & Lappi, 1994). The antibody and immunotoxin undergo retrograde transport.
      Species Reactivity
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide.
      Gene Symbol
      • DBH
      • DBM
      • EC [Contains: Soluble dopamine beta-hydroxylase].
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P09172 # Conversion of dopamine to noradrenaline.
      COFACTOR: Binds 1 PQQ per subunit. & Binds 2 copper ions per subunit.
      SIZE: 617 amino acids; 69065 Da
      SUBUNIT: Homotetramer composed of two non-covalently bound disulfide-linked dimers.
      SUBCELLULAR LOCATION: Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. & Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single- pass type II membrane protein (Potential).
      DISEASE: SwissProt: P09172 # Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.
      SIMILARITY: SwissProt: P09172 ## Belongs to the copper type II ascorbate-dependent monooxygenase family. & Contains 1 DOMON domain.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe material should be stored at -80°C for up to six months under sterile conditions. Avoid repeated freeze-thaw cycles.
      Packaging Information
      Material Size250 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      ANTI-DOPAMINE β-HYDROXYLASE (DBH)-SAP -2514950 2514950
      ANTI-DOPAMINE β-HYDROXYLASE (DBH)-SAP -2517320 2517320
      ANTI-DOPAMINE β-HYDROXYLASE (DBH)-SAP -2619121 2619121


      Reference overviewPub Med ID
      Central noradrenergic lesioning using anti-DBH-saporin: anatomical findings.
      Wrenn, C C, et al.
      Brain Res., 740: 175-84 (1996) 1996

      Show Abstract
      8973812 8973812
      Anti-dopamine beta-hydroxylase immunotoxin-induced sympathectomy in adult rats.
      Picklo, M J, et al.
      J. Pharmacol. Exp. Ther., 275: 1003-10 (1995) 1995

      Show Abstract
      7473126 7473126
      Soluble and membrane-bound forms of dopamine beta-hydroxylase are encoded by the same mRNA.
      Lewis, E J and Asnani, L P
      J. Biol. Chem., 267: 494-500 (1992) 1992

      Show Abstract
      1730612 1730612

      Data Sheet

      Anti-Dopamine Beta Hydroxylase-SAP (Saporin Conjugated), clone 4F10.2 - Data Sheet

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      Alternative Packsize

      Catalog Number Description  
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      Life Science Research > Antibodies and Assays > Primary Antibodies