A part of MilliporeSigma

ABD122 | Anti-Dishevelled Antibody

ABD122
100 µL  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB, ICC Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberABD122
      DescriptionAnti-Dishevelled Antibody
      Alternate Names
      • DSH
      • DVL1
      • DVL2
      • DVL3
      • DSH Homolog 1
      Background InformationDishevelled (DVL1), the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation. The protein acts as a transducer molecule for developmental processes, including segmentation and neuroblast specification. Dishevelled plays a role both in canonical and non-canonical Wnt signaling. DVL1 mutation is likely responsible for transformation in neuroblastomas, and the Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1 gene, thus Dishevelled maybe important in these diseases as well.
      References
      Product Information
      FormatSerum
      PresentationRabbit polyclonal serum containing 0.05% sodium azide.
      Applications
      ApplicationThis Anti-Dishevelled Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of Dishevelled.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A representative lot was used by an independent laboratory in PC12 cells. (Kishida et al., 2007. Dvl regulates endo- and exocytotic processes through binding to synaptotagmin. Genes to Cells, 12, 49–61).
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to Human Dishevelled.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityRecognizes Human, Mouse and Rat Dishevelled 1, 2 and 3.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • DVL1
      • DVL2
      • DVL3
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~ 81 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HEK293T cell lysate.

      Western Blot Analysis: A 1:1000 of this antibody detected Dishevelled in 10 µg of HEK293T cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Dishevelled - Q2467699 Q2467699

      References

      Reference overviewPub Med ID
      Dvl regulates endo- and exocytotic processes through binding to synaptotagmin.
      Kishida, Shosei, et al.
      Genes Cells, 12: 49-61 (2007) 2007

      Show Abstract
      17212654 17212654
      Wnt-3a and Dvl induce neurite retraction by activating Rho-associated kinase.
      Kishida, S; Yamamoto, H; Kikuchi, A
      Molecular and cellular biology 24 4487-501 2004

      Show Abstract
      15121866 15121866
      DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.
      Kishida, S, et al.
      Mol. Cell. Biol., 19: 4414-22 (1999) 1999

      Show Abstract
      10330181 10330181

      Related Products & Applications

      Related Products

      Catalog Number Description  
      AB5970 Anti-Dishevelled-1 Antibody Show Pricing & Availability
      AB5972 Anti-Dishevelled-2 Antibody Show Pricing & Availability
      AB5976 Anti-Dishevelled-2 Antibody Show Pricing & Availability

      View Gene Related Products for this Target

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies