A part of MilliporeSigma

MAB4356 | Anti-DPPA-2 Antibody, clone 6C1.2

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M WB M Purified Monoclonal Antibody
      Catalogue NumberMAB4356
      DescriptionAnti-DPPA-2 Antibody, clone 6C1.2
      Alternate Names
      • Pluripotent embryonic stem cell-related gene 1 protein
      • developmental pluripotency associated 2
      Background InformationDPPA-2 (developmental pluripotency associated-2) is a novel Oct-4-related protein that is localized to the nucleus of mouse fetal germ cells. DPPA-2 has binding sites for both POU and Sox-2 protein domains and is expressed primarily in the developing germ line following gastrulation. These associations suggest that this protein participates in a very strong supportive role in maintaining cell pluripotentiality. In addition to its role as a pluripotency marker, more recent research using cancer cells suggests that DPPA-2 may also act as an embryo-cancer antigen—pointing to the presence of abnormal cell growth and the formation of cancerous cells.
      Product Information
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4) and
      150 mM NaCl with 0.05% sodium azide.
      ApplicationThis Anti-DPPA-2 Antibody, clone 6C1.2 is validated for use in WB for the detection of DPPA-2.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenFull length recombinant mouse DPPA-2 protein.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis monoclonal antibody recognizes the mouse DPPA-2 protein.
      Species Reactivity
      • Mouse
      Species Reactivity NoteReacts with mouse. Reactivity with other species has not been tested.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PESCRG1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: May play a role in maintaining cell pluripotentiality.
      TISSUE SPECIFICITY: Expressed in embryonic stem cells. No expression is seen in 5 months embryo, mesenchymal stem cells, embryonic fibrocytes and adult tissues.
      SEQUENCE SIMILARITIES: Contains 1 SAP domain.
      Stem Cell Type
      • Mouse Embryonic Stem Cells
      Molecular Weight~34 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance(Based upon representative data from a previous lot).
      Western Blotting: Recommended working concentration is 2 µg/mL.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information