A part of MilliporeSigma

ABT291 | Anti-DOCK3 Antibody

150 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC, ICC Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABT291
      DescriptionAnti-DOCK3 Antibody
      Alternate Names
      • Modifier of cell adhesion
      • dedicator of cytokinesis 3
      • Presenilin binding protein
      Background InformationDedicator of cytokinesis3 (DOCK3) is a potential guanine nucleotide exchange factor (GEF) which activates GTPases by exchanging bound GDP for free GTP. DOCK3 is associated in Alzheimer disease tangles and regulates the accumulation of amyloid precursor protein and beta-amyloid. Overexpression of DOCK3 in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling. DOCK3 binds to and inactivates glycogen synthase kinase-3β (GSK-3β) at the plasma membrane, thereby promoting axon branching and microtubule assembly. By stimulating actin polymerization and microtubule assembly, DOCK3 plays important roles downstream of BDNF signaling in the CNS.
      Product Information
      FormatAffinity Purified
      • Human brain tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide and 50% glycerol.
      ApplicationAnti-DOCK3 detects levels of DOCK3 proteins & has been published & validated for use in WB, IHC & ICC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunocytochemistry
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected DOCK3 in normal human brain and Alzheimer's brain tissues.

      Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected DOCK3 in A431 and HeLa cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human DOCK3.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • DOCK3
      • MOCA
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~233 kDa observed. Uncharacterized bands may appear at ~17 kDa and ~50 kDa in some lysates.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human brain tissue lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected DOCK3 in 10 µg of human brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size150 µL
      Transport Information
      Supplemental Information