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07-688 | Anti-DNMT1 Antibody

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Serum Polyclonal Antibody
      Catalogue Number07-688
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-DNMT1 Antibody
      Product Information
      ApplicationDetect DNMT1 also known as DNA (cytosine-5)-methyltransferase 1 with Anti-DNMT1 Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenfusion protein corresponding to residues 913-1085 of human DNA methyltransferase 1 (DNMT1)
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryDNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities.
      Gene Symbol
      • DNMT1
      • Dnmt1
      • M.HsaI
      • DNA
      • FLJ16293
      • MCMT
      • AIM
      • DNMT
      • CXXC9
      • MGC104992
      Purification MethodSerum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P26358 # Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2.
      SIZE: 1616 amino acids; 183165 Da
      SUBUNIT: Interacts with HDAC1 and with PCNA. Forms a complex with DMAP1 and HDAC2, with direct interaction. Forms also a stable complex with E2F1, BB1 and HDAC1. Binds MBD2 and MBD3. Component of complexes containing SUV39H1.
      TISSUE SPECIFICITY: Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1.
      SIMILARITY: SwissProt: P26358 ## Belongs to the C5-methyltransferase family. & Contains 2 BAH domains. & Contains 1 CXXC-type zinc finger.
      Molecular Weight220kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot with RIPA lysates from HeLa nuclear extracts.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-DNMT1 - 30370 30370
      Anti-DNMT1 -2647465 2647465
      Anti-DNMT1 -2784037 2784037


      Reference overviewPub Med ID
      Selective anti-leukaemic activity of low-dose histone deacetylase inhibitor ITF2357 on AML1/ETO-positive cells.
      Barbetti, V; Gozzini, A; Rovida, E; Morandi, A; Spinelli, E; Fossati, G; Mascagni, P; Lübbert, M; Dello Sbarba, P; Santini, V
      Oncogene 27 1767-78 2008

      Show Abstract
      17891169 17891169
      DNA methylation and chromatin - unraveling the tangled web.
      Robertson, Keith D
      Oncogene, 21: 5361-79 (2002) 2002

      Show Abstract
      12154399 12154399
      The DNA methyltransferases of mammals.
      Bestor, T H
      Hum. Mol. Genet., 9: 2395-402 (2000) 2000

      11005794 11005794
      Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
      Li, E, et al.
      Cell, 69: 915-26 (1992) 1992

      Show Abstract
      1606615 1606615

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      Catalog Number Description  
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      Life Science Research > Antibodies and Assays > Primary Antibodies