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MABD10 | Anti-DMP1, NT Antibody, clone 9B6.3

100 µg  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R WB M Purified Monoclonal Antibody
      Catalogue NumberMABD10
      DescriptionAnti-DMP1, NT Antibody, clone 9B6.3
      Alternate Names
      • Dentin matrix acidic phosphoprotein 1
      • DMP-1
      • Dentin matrix protein 1
      • AG1
      Background InformationDentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.
      Product Information
      • Rat dentin tissue extract
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationDetect DMP1, N-terminus using this Anti-DMP1, N-terminus Antibody, clone 9B6.3 validated for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenN-terminus fragment of rat DMP1 isolated from long bone.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes the N-terminus of DMP1.
      Species Reactivity
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Dmp1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~65 kDa observed. Uniprot describes a molecular weight at ~53 kDa. Uniprot describes that this protein is highly phosphorylated and highly glycosolated.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in rat dentin tissue extract.

      Western Blot Analysis: 1 µg/mL of this antibody detected DMP1 in 10 µg of rat dentin tissue extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies