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MABN759 | Anti-DISC1 Antibody, clone 3D4

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H IH(P), WB, ICC M Purified Monoclonal Antibody
      Catalogue NumberMABN759
      DescriptionAnti-DISC1 Antibody, clone 3D4
      Alternate Names
      • Disrupted in schizophrenia 1 protein
      Background InformationDisrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3epsilon from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC1 has at least four known isoforms.
      Product Information
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationThis Anti-DISC1 Antibody, clone 3D4 is validated for use in IHC (Paraffin), western blotting andICC for the detection of DISC1.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected DISC1 in human cerebellum and human cerebral cortex tissue.
      Western Blotting Analysis: A representative lot detected DISC1 in human NLF cell lysate (Leliveld, S. R., et al. (2008). Journal of Neuroscience. 28(15):3839-3845).
      Immunocytochemistry Analysis: A representative lot detected DISC1 in transfected cells (Bader, V., et al. (2012). Human Molecular Genetics. 21(20):4406-4418).
      Immunohistochemistry Analysis: A representative lot detected DISC1 in human cortical tissue sections (Seshadri, S. et al. (2010). PNAS. 107(12):5622-5627).
      Immunohistochemistry Analysis: A representative lot detected DISC1 in human brain tissue (Bader, V., et al. (2012). Human Molecular Genetics. 21(20):4406-4418).
      Biological Information
      ImmunogenRecombinant protein corresponding to human DISC1.
      Concentration1 mg/mL
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • DISC1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight94 kDa calculated
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human cerebral cortex tissue.

      Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected DISC1 in human cerebral cortex tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-DISC1, clone 3D4 - Q2428563 Q2428563
      Anti-DISC1, clone 3D4 -2705159 2705159


      Reference overviewPub Med ID
      Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits.
      Bader, Verian, et al.
      Hum. Mol. Genet., 21: 4406-18 (2012) 2012

      Show Abstract
      22798627 22798627
      Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade.
      Seshadri, Saurav, et al.
      Proc. Natl. Acad. Sci. U.S.A., 107: 5622-7 (2010) 2010

      Show Abstract
      20212127 20212127
      Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease.
      Leliveld, S Rutger, et al.
      J. Neurosci., 28: 3839-45 (2008) 2008

      Show Abstract
      18400883 18400883

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      Life Science Research > Antibodies and Assays > Primary Antibodies