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MABF39 | Anti-DC-STAMP Antibody, clone 1A2

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H WB, FC, ICC M Purified Monoclonal Antibody
      Catalogue NumberMABF39
      DescriptionAnti-DC-STAMP Antibody, clone 1A2
      Alternate Names
      • transmembrane 7 superfamily member 4
      • DC-specific transmembrane protein
      • IL-Four INDuced
      • IL-Four (IL-4) induced
      • Dendritic cell-specific transmembrane protein
      • Dendritic cells (DC)-specific transmembrane protein
      • IL-4-induced protein
      Background InformationDendritic cell-specific transmembrane protein (DC-STAMP) is a recently described, 470-amino acid, transmembrane protein with a critical role in TNSF11-mediated osteogenesis and giant cell formation. It has also been implicated in a role for inducing tartrate-resistant acid phosphatase expression in osteoclast precursors. DC-STAMP was originally discovered in myeloid dendritic cells as an interleukin-4 (IL-4)-inducible protein consisting of seven transmembrane domains. DC-STAMP is widely expressed with highest levels observed in kidney, liver, lung and lymph node, along with preferential expression in both mature and immature dendritic cells. Lower levels of expression have been observed in bone marrow, leukocytes, pancreas and spleen, and also in freshly isolated B-cells and peripheral blood mononuclear cells (PBMC).
      Product Information
      • RAW 264.7 cell lysate
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-DC-STAMP Antibody, clone 1A2 detects level of DC-STAMP & has been published & validated for use in WB, FC & IC.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: This antibody has been shown to detect DC-STAMP in IC (Mensah, K.A., et al., 2010).

      Flow Cytometry Analysis: This antibody has been shown to detect DC-STAMP in FC (Mensah, K.A., et al., 2010).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human DC-STAMP at the fourth extracellular domain.
      EpitopeFourth Extracellular Domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes DC-STAMP at the fourth extracellular domain.
      Species Reactivity
      • Mouse
      • Human
      Species Reactivity NoteDemonstrated to react with mouse.
      Predicted to react with human based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryDendritic cells are unique in their ability to present antigen to naive T cells, and therefore play a central role in the initiation of immune responses. The protein encoded by this gene is a transmembrane molecule that is preferentially expressed by dendritic cells. Its expression is down-regulated by ligation of the CD40 molecule. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq].
      Gene Symbol
      • FIND
      • DC-STAMP
      • DCSTAMP
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Plays an essential role in TNFSF11-mediated osteoclastogenesis. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors (By similarity).

      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein Potential. Note: Localized to the cell surface. Ref.1

      TISSUE SPECIFICITY: Highly expressed in lymph nodes, lung, kidney and liver. Expressed at lower levels in pancreas, bone marrow, spleen and leukocytes. Preferentially expressed by dendritic cells. Detected in both immature and mature dendritic cells. Expressed at lower levels in freshly isolated peripheral blood mononuclear cells (PBMC) and B-cells. Not expressed in freshly isolated monocytes.

      DEVELOPMENTAL STAGE: Constitutively expressed in dendritic cells from day 3-8 in culture.

      INDUCTION: Expression is down-regulated by dexamethasone and up-regulated by IL-4. Down-regulated in CD40 ligand activated dendritic cells.
      Molecular WeightThis antibody detects the ~106 kDa dimeric and the ~53 kDa monomeric DC-STAMP in non-denaturing and denaturing conditions (Mensah, K.A., et al., 2010).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in RAW 264.7 cell lysate.

      Western Blot Analysis: 2 µg/mL of this antibody detected DC-STAMP in 10 µg of RAW 264.7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-DC-STAMP, clone 1A2 2461551
      Anti-DC-STAMP, clone 1A2 - 1956738 1956738
      Anti-DC-STAMP, clone 1A2 - 2066714 2066714
      Anti-DC-STAMP, clone 1A2 - 2204955 2204955
      Anti-DC-STAMP, clone 1A2 - 2290987 2290987
      Anti-DC-STAMP, clone 1A2 - 2360594 2360594
      Anti-DC-STAMP, clone 1A2 - NG1808959 NG1808959
      Anti-DC-STAMP, clone 1A2 - NG1825185 NG1825185
      Anti-DC-STAMP, clone 1A2 - NG1900695 NG1900695
      Anti-DC-STAMP, clone 1A2 - NRG1761321 NRG1761321
      Anti-DC-STAMP, clone 1A2 -2480848 2480848
      Anti-DC-STAMP, clone 1A2 -2514241 2514241


      Reference overviewApplicationSpeciesPub Med ID
      The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells.
      Gurt, I; Artsi, H; Cohen-Kfir, E; Hamdani, G; Ben-Shalom, G; Feinstein, B; El-Haj, M; Dresner-Pollak, R
      PloS one 10 e0134391 2015

      Show Abstract
      26226624 26226624
      Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP).
      Chiu, Ya-Hui, et al.
      J. Bone Miner. Res., (2012) 27 2012

      Show Abstract
      Immunoblotting (Western)Human21987375 21987375

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