A part of MilliporeSigma

MAB1612 | Anti-Cytokeratin Epithelial Antibody, clone AE1

500 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, Ch, H, M, R, Rb IH(P) M Purified Monoclonal Antibody
      Catalogue NumberMAB1612
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Cytokeratin Epithelial Antibody, clone AE1
      Product Information
      PresentationLiquid in 0.05M Borate Buffered Saline, 0.15M NaCl, 0.09% Sodium Azide, pH8.2.
      ApplicationThis Anti-Cytokeratin Epithelial Antibody, clone AE1 is validated for use in IH(P) for the detection of Cytokeratin Epithelial.
      Key Applications
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry on unfixed frozen sections and formalin-fixed paraffin embedded tissues. Antigen retrieval is recommended. HEIR or protease treatment can be used.

      Western Blotting: AE1 recognizes LMW cytokeratins from the acidic subfamily including: Clone AE1 recognises the 56.5, 50, 50', 48 and 40kD human cytokeratins of the acidic subfamily.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenHuman epidermal keratin
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityRecognizes most of the acidic (Type I) keratins. It is broadly reactive and stains positively almost all epithelia and their neoplasms. MAB1612 produces heterogeneous staining within a given epithelium; the detailed staining pattern varies depending on the differentiated and/or growth state of individual cells.
      Species Reactivity
      • Bovine
      • Chicken
      • Human
      • Mouse
      • Rat
      • Rabbit
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KRT8
      • KO
      • K8
      • CYK8
      • Keratin-8
      • CK-8
      • Cytokeratin-8
      • K2C8
      • CK8
      • CARD2
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05787 # Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
      SIZE: 483 amino acids; 53704 Da
      SUBUNIT: Heterotetramer of two type I and two type II keratins. keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP.
      TISSUE SPECIFICITY: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
      PTM: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
      DISEASE:SwissProt: P05787 # Defects in KRT8 are a cause of cryptogenic cirrhosis [MIM:215600].
      SIMILARITY: SwissProt: P05787 ## Belongs to the intermediate filament family.
      MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months.
      Packaging Information
      Material Size500 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-KERATIN, EPITHELIAL -2586420 2586420
      MOUSE ANTI-KERATIN, EPITHELIAL -2608417 2608417
      MOUSE ANTI-KERATIN, EPITHELIAL -2658921 2658921
      MOUSE ANTI-KERATIN, EPITHELIAL -2667317 2667317
      MOUSE ANTI-KERATIN, EPITHELIAL -2683936 2683936
      MOUSE ANTI-KERATIN, EPITHELIAL -2791993 2791993
      MOUSE ANTI-KERATIN, EPITHELIAL -2821220 2821220


      Reference overviewPub Med ID
      Changes in keratin expression during metastatic progression of breast cancer: impact on the detection of circulating tumor cells.
      Joosse, SA; Hannemann, J; Spötter, J; Bauche, A; Andreas, A; Müller, V; Pantel, K
      Clinical cancer research : an official journal of the American Association for Cancer Research 18 993-1003 2012

      Show Abstract
      22228641 22228641
      Disseminated tumor cells as selection marker and monitoring tool for secondary adjuvant treatment in early breast cancer. Descriptive results from an intervention study.
      Synnestvedt, M; Borgen, E; Wist, E; Wiedswang, G; Weyde, K; Risberg, T; Kersten, C; Mjaaland, I; Vindi, L; Schirmer, C; Nesland, JM; Naume, B
      BMC cancer 12 616 2012

      Show Abstract
      23259667 23259667

      Data Sheet

      Anti-Cytokeratin Epithelial, clone AE1 - Data Sheet

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      Alternative Packsize

      Catalog Number Description  
      MAB1612-K Anti-Keratin, Epithelial, clone AE1 (1mg) Show Pricing & Availability

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      Life Science Research > Antibodies and Assays > Primary Antibodies