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MAB1677 | Anti-Cytokeratin 17 Antibody, clone E3

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R ICC, IF, IHC, WB M Ascites Monoclonal Antibody
      Catalogue NumberMAB1677
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Cytokeratin 17 Antibody, clone E3
      Alternate Names
      • Keratin, type I cytoskeletal 17
      • Cytokeratin-17
      • CK-17
      • Keratin-17
      • K17
      • Type I keratin Ka17
      Product Information
      PresentationAscites with no preservatives.
      ApplicationAnti-Cytokeratin 17 Antibody, clone E3 is an antibody against Cytokeratin 17 for use in WB, IC, IH(P).
      Key Applications
      • Immunocytochemistry
      • Immunofluorescence
      • Immunohistochemistry
      • Western Blotting
      Application NotesImmunocytochemistry Analysis: A representative lot immunostained intermediate filaments in 1 % Triton X-100-permeabilized, 4% formaldehyde-fixed HeLa cells by indirect immunofluorescence (Troyanovsky, S.M., et al. (1989). J. Cell Sci. 93(Pt 3):419-426).

      Immunofluorescence Analysis: A representative lot localized cytokeratin 17 immunoreactivity in cryosections from human salivary glands, urinary bladder, sebaceous gland and hair folliculus by indirect immunofluorescence (Troyanovsky, S.M., et al. (1989). J. Cell Sci. 93(Pt 3):419-426).

      Immunohistochemistry Analysis: A representative lot immunostained newly regenerated hair follicles after wounding in 4% paraformaldehyde-fixed rat skin epidermal tissue expressing transfected hTERT (Jan, H.M., et al. (2012). Gene Ther. 19(1):86-93).

      Western Blotting Analysis: A representative lot detected cytokeratin 17 in HeLa total cell lysate as well as in intermediate filaments/IF-enriched cytoskeletal fractions from HeLa cells, human bronchus tissue, Papilloma of the human mammary gland, and transitional cell papilloma of the human urinary bladder (Troyanovsky, S.M., et al. (1989). J. Cell Sci. 93(Pt 3):419-426).
      Biological Information
      ImmunogenCytoskeletal preparation from rat colon (Troyanovsky, S.M., et al. (1989). J. Cell Sci. 93(Pt 3):419-426).
      SpecificityClone E3 immunostained intermediate filaments in HeLa cells by indirect immunofluorescence (Troyanovsky, S.M., et al. (1989). J. Cell Sci. 93(Pt 3):419-426).
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryKRT17 encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.
      Gene Symbol
      • Krt17
      • Ka17
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q6IFU8 # May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair (By similarity).
      SIZE: 433 amino acids; 48123 Da
      SUBUNIT: Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers. Interacts with TRADD and SFN (By similarity).
      SUBCELLULAR LOCATION: Cytoplasm (By similarity).
      TISSUE SPECIFICITY: Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).
      SIMILARITY: SwissProt: Q6IFU8 ## Belongs to the intermediate filament family.
      Molecular Weight48.11/48.12 kDa (human/rat) calculated. ~47 kDa reported (Troyanovsky, S.M., et al. (1989). J. Cell Sci. 93(Pt 3):419-426).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-KERATIN 17 -2545377 2545377
      MOUSE ANTI-KERATIN 17 -2638873 2638873
      MOUSE ANTI-KERATIN 17 -2664452 2664452


      Reference overviewPub Med ID
      The use of polyethylenimine-DNA to topically deliver hTERT to promote hair growth.
      H-M Jan,M-F Wei,C-L Peng,S-J Lin,P-S Lai,M-J Shieh
      Gene therapy 19 2012

      Show Abstract
      21593794 21593794
      Patterns of expression of keratin 17 in human epithelia: dependency on cell position.
      Troyanovsky, S M, et al.
      J. Cell. Sci., 93 ( Pt 3): 419-26 (1989) 1989

      Show Abstract
      2481679 2481679
      Monoclonal antibody mapping of keratins 8 and 17 and of vimentin in normal human mammary gland, benign tumors, dysplasias and breast cancer.
      Guelstein, V I, et al.
      Int. J. Cancer, 42: 147-53 (1988) 1988

      Show Abstract
      2456993 2456993

      Data Sheet

      Anti-Cytokeratin 17, clone E3 - Data Sheet