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MAB3684 | Anti-Cyclin B1 Antibody, clone V152

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB, IH(P) M Ascites Monoclonal Antibody
      Catalogue NumberMAB3684
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Cyclin B1 Antibody, clone V152
      Product Information
      PresentationAscites fluid. Liquid. Contains no preservative.
      ApplicationDetect Cyclin B1 with Anti-Cyclin B1 Antibody, clone V152 (Mouse Monoclonal Antibody), that has been shown to work in WB, IHC(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern blot

      Immunohistochemistry (works on paraffin embedded tissue sections)

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenHamster Cyclin B1.
      SpecificityCyclin B. Cyclin B1 is a marker of cell proliferation and a key component of the cell progression machinery. MAB3684 works well for detecting Cyclin B1 by Western blot and immunohistochemistry.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites.
      Gene Symbol
      • CCNB1
      • CCNB
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P14635 # Essential for the control of the cell cycle at the G2/M (mitosis) transition.
      SIZE: 433 amino acids; 48337 Da
      SUBUNIT: Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase.
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Centrosome.
      DEVELOPMENTAL STAGE: Accumulates steadily during G2 and is abruptly destroyed at mitosis.
      PTM: Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.
      SIMILARITY: SwissProt: P14635 ## Belongs to the cyclin family. Cyclin AB subfamily.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-CYCLIN B1 -2583384 2583384
      MOUSE ANTI-CYCLIN B1 -2639920 2639920
      MOUSE ANTI-CYCLIN B1 -2770825 2770825


      Reference overviewApplicationPub Med ID
      TopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeres.
      d'Alcontres, MS; Palacios, JA; Mejias, D; Blasco, MA
      Cell cycle (Georgetown, Tex.) 13 1463-81 2014

      Show Abstract
      24626180 24626180
      Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1).
      Trakala, M; Fernández-Miranda, G; Pérez de Castro, I; Heeschen, C; Malumbres, M
      Cell cycle (Georgetown, Tex.) 12 1030-41 2013

      Show Abstract
      Immunofluorescence23428904 23428904
      Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis.
      Chen, Y; Gridley, T
      Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 28 1412-21 2013

      Show Abstract
      23322385 23322385
      Lin28 modulates cell growth and associates with a subset of cell cycle regulator mRNAs in mouse embryonic stem cells.
      Xu, B; Zhang, K; Huang, Y
      RNA (New York, N.Y.) 15 357-61 2009

      Show Abstract Full Text Article
      19147696 19147696
      Iron-independent phosphorylation of iron regulatory protein 2 regulates ferritin during the cell cycle.
      Wallander, ML; Zumbrennen, KB; Rodansky, ES; Romney, SJ; Leibold, EA
      The Journal of biological chemistry 283 23589-98 2008

      Show Abstract
      18574241 18574241
      Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.
      Geley, S, et al.
      J. Cell Biol., 153: 137-48 (2001) 2001

      Show Abstract
      11285280 11285280

      Data Sheet

      Anti-Cyclin B1, clone V152 - Data Sheet

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      Life Science Research > Antibodies and Assays > Primary Antibodies