MAB3680 Anti-Cyclin A Antibody, clone E23.1

MAB3680
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, H, M WB, ICC M Ascites Monoclonal Antibody
      Description
      Catalogue NumberMAB3680
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Cyclin A Antibody, clone E23.1
      References
      Product Information
      FormatAscites
      PresentationAscites fluid. Liquid. Contains no preservative.
      Applications
      ApplicationDetect Cyclin A with Anti-Cyclin A Antibody, clone E23.1 (Mouse Monoclonal Antibody), that has been shown to work in WB, ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesWestern blot

      Immunocytochemistry

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenBovine Cyclin A fusion protein.
      CloneE23.1
      HostMouse
      SpecificityCyclin A. Cyclin A protein is absent in cells prior to S-phase, during which its levels increase and peak. MAB3680 is extremely sensitive for immunoblotting of Cyclin A. Cyclin A is involved in the regulation of the cell cycle and is essential for progression through S phase. Cyclin A is a marker for actively proliferating cells and for cells in S phase.
      IsotypeIgG2a
      Species Reactivity
      • Bovine
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • CCNA1
      • Cyclin-A1.
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P78396 # May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
      SIZE: 465 amino acids; 52358 Da
      SUBUNIT: Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with KLHDC9.
      TISSUE SPECIFICITY: Very high levels in testis and very low levels in brain. Also found in myeloid Leukemia cell lines.
      DEVELOPMENTAL STAGE: Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases.
      SIMILARITY: SwissProt: P78396 ## Belongs to the cyclin family. Cyclin AB subfamily.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Cyclin A Antibody, clone E23.1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Cyclin A Antibody, clone E23.1 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-CYCLIN A - 32825173282517
      MOUSE ANTI-CYCLIN A -25240612524061
      MOUSE ANTI-CYCLIN A -25755302575530
      MOUSE ANTI-CYCLIN A -26245692624569
      MOUSE ANTI-CYCLIN A -26731102673110
      MOUSE ANTI-CYCLIN A -28186882818688
      MOUSE ANTI-CYCLIN A MONOCLONAL ANTIBODY2961157
      MOUSE ANTI-CYCLIN A MONOCLONAL ANTIBODY2896066

      Data Sheet

      Title
      Anti-Cyclin A, clone E23.1 - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies