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06-138 | Anti-Cyclin A Antibody

200 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R, Sh IP, WB, ICC Rb Purified Polyclonal Antibody
      Catalogue Number06-138
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Cyclin A Antibody
      Background InformationThe cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle. Cyclins combine with cyclin dependent kinases (cdks) to form activated kinases that phosphorylate targets leading to cell cycle regulation. A breakdown in the regulation of this cycle can lead to out of control growth and contribute to tumor formation. Defects in many of the molecules that regulate the cell cycle have been implicated in cancer. Cyclin A is a member of the Cyclin A family that can bind and activate Cdc2 and Cdk2 and is involved in the control of mitosis and S phase. During S phase, cyclin A forms a complex with Cdk2, the pRB-related protein p107 and E2F.
      Product Information
      • Daudi cells
      ApplicationDetect Cyclin A with Anti-Cyclin A Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP, WB, ICC.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunocytochemistry
      Biological Information
      Immunogenpeptide corresponding amino acid residues 417-432 (C-KHGVSLLNPPETL-N-L)
      Specificityp58cyclin A; does not cross-react with cyclin B or cyclin D2, or 3
      Species Reactivity
      • Human
      • Mouse
      • Rat
      • Sheep
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.
      Gene Symbol
      • CCNA2
      • Cyclin-A2
      • CCN1
      • Cyclin-A
      • CCNA
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P20248 # Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.
      SIZE: 432 amino acids; 48537 Da
      SUBUNIT: Interacts with the CDK2 and CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
      DEVELOPMENTAL STAGE: Accumulates steadily during G2 and is abruptly destroyed at mitosis.
      SIMILARITY: SwissProt: P20248 ## Belongs to the cyclin family. Cyclin AB subfamily.
      Molecular Weight58kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on HeLa nuclear extract
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Cyclin A 2476954
      Anti-Cyclin A - 12189 12189
      Anti-Cyclin A - 17553 17553
      Anti-Cyclin A - 21306 21306
      Anti-Cyclin A - 26059 26059

      References | 21 Available | See All References

      Reference overviewApplicationPub Med ID
      Efficient parvovirus replication requires CRL4Cdt2-targeted depletion of p21 to prevent its inhibitory interaction with PCNA.
      Adeyemi, RO; Fuller, MS; Pintel, DJ
      PLoS pathogens 10 e1004055 2014

      Show Abstract
      24699724 24699724
      Parvovirus-induced depletion of cyclin B1 prevents mitotic entry of infected cells.
      Adeyemi, RO; Pintel, DJ
      PLoS pathogens 10 e1003891 2014

      Show Abstract
      24415942 24415942
      The kinetics of G2 and M transitions regulated by B cyclins.
      Huang, Y; Sramkoski, RM; Jacobberger, JW
      PloS one 8 e80861 2013

      Show Abstract
      24324638 24324638
      TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.
      Liu, K; Ling, S; Lin, WC
      Molecular and cellular biology 31 4464-81 2011

      Show Abstract
      21930790 21930790
      Lin28 modulates cell growth and associates with a subset of cell cycle regulator mRNAs in mouse embryonic stem cells.
      Xu, B; Zhang, K; Huang, Y
      RNA (New York, N.Y.) 15 357-61 2009

      Show Abstract Full Text Article
      19147696 19147696
      Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer.
      Liu, K; Bellam, N; Lin, HY; Wang, B; Stockard, CR; Grizzle, WE; Lin, WC
      Molecular and cellular biology 29 2673-93 2009

      Show Abstract
      19289498 19289498
      Cyclooxygenase-2 overexpression in MCF-10F human breast epithelial cells inhibits proliferation, apoptosis and differentiation, and causes partial transformation.
      Suying Lu, Guo Yu, Yonghong Zhu, Michael C Archer
      International journal of cancer. Journal international du cancer 116 847-52 2005

      Show Abstract
      15856465 15856465
      Roles of polo-like kinase 1 in the assembly of functional mitotic spindles.
      Izabela Sumara, Juan F Giménez-Abián, Daniel Gerlich, Toru Hirota, Claudine Kraft, Consuelo de la Torre, Jan Ellenberg, Jan-Michael Peters
      Current biology : CB 14 1712-22 2004

      Show Abstract
      15458642 15458642
      Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations.
      Wong, S; McLaughlin, J; Cheng, D; Zhang, C; Shokat, KM; Witte, ON
      Proceedings of the National Academy of Sciences of the United States of America 101 17456-61 2004

      Show Abstract Full Text Article
      15505216 15505216
      The human histone gene expression regulator HBP/SLBP is required for histone and DNA synthesis, cell cycle progression and cell proliferation in mitotic cells.
      Zhao, X; McKillop-Smith, S; Müller, B
      Journal of cell science 117 6043-51 2004

      Show Abstract
      15546920 15546920

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