A part of MilliporeSigma

ABC924 | Anti-CtBP-2 Antibody

100 μg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABC924
      DescriptionAnti-CtBP-2 Antibody
      Alternate Names
      • C-terminal-binding protein 2
      • CtBP-2
      • CtBP2
      Background InformationC-terminal-binding protein 2 (UniProt P56545; also known as CtBP2) is a nuclear protein encoded by the CTBP2 gene (Gene ID 1488) in human. CtBP1 and CtBP2 are closely related proteins that are encoded by the vertebrate genome and perform both unique and duplicative functions. Upon activation by nicotinamide adenine dinucleotide binding to their dehydrogenase domains, CtBP1 and CtBP2 exert transcriptional repression activity primarily via recruitment of a corepressor complex that consists of histone deacetylases (HDACs) and histone methyltransferases, although CtBPs can also repress transcription through HDAC-independent mechanisms. A critical function of CtBPs lies in the transcriptional repression of pro-apoptotic genes such as Bax, Puma, Bik, and Noxa. CtBP2 is essential for proper development of the nervous system. Acetylation by histone acetyl transferase p300 regulates CtBP2 activity and subcellular localization, while microenvironmental oxygen levels influences the dimerization, acetylation, and thereby the activity of CtBP2 in proliferating neural stem cells (NSCs).
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationThis Anti-CtBP-2 Antibody is validated for use in Western Blotting, Immunohistochemistry for the detection of CtBP-2 .
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected CtBP-2 in human breast cancer cells, human kidney, human ovarian cancer cells, and human prostate cancer cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human CtBP-2.
      ConcentrationPlease refer to lot specific datasheet.
      SpecificityExpected to react with spliced variant Ribeye (isoform 2).
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Mouse, Horse, Bovine, Chicken, Porcine, Ovine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CTBP2
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~50 kDa observed. 48.9 kDa (Isoform 1; calculated); 109.2 kDa (Isoform 2/Ribeye; calculated)." ==> ~50 kDa observed. 48.9 kDa (Isoform 1; calculated); 109.2 kDa (Isoform 2/Ribeye; calculated).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: 0.25 µg/mL of this antibody detected CtBP-2 in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information