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ABD13 | Anti-Cripto-1 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABD13
      DescriptionAnti-Cripto-1 Antibody
      Alternate Names
      • Teratocarcinoma-derived growth factor 1
      • Cripto-1 growth factor
      • CRGF
      • Epidermal growth factor-like cripto protein CR1
      • TDGF1
      Background InformationCripto-1 growth factor (Cripto-1), also known as teratocarcinoma-derived growth factor 1 (TDGF1), is a member of the epidermal growth factor-CFC family and is important for embryonic development. Cripto-1 has been shown to be up-regulated in many different human cancers and could be a possible therapeutic target for cancer. There is also promising research surrounding a cancer vaccine that uses Cripto-1 as a target.
      Product Information
      FormatAffinity Purified
      • NT2/D1 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationThis Anti-Cripto-1 Antibody is validated for use in WB for the detection of Cripto-1.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Cripto-1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with Human. No homology to Mouse or Rat found.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq].
      Gene Symbol
      • TDGF1
      • CRIPTO
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

      SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor › GPI-anchor

      TISSUE SPECIFICTY: Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts.

      SEQUENCE SIMILARITIES: Contains 1 EGF-like domain.
      Molecular Weight~18 kDa and ~35 kDa observed. An uncharacterized band may appear at ~62 kDa in some lysates. The observed molecular weight at ~35 kDa may be the result of glycosylsation. (Brandt, R., et al. (1994). The Journal of Biological Chemistry. 269(25):17320-17328.)
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in NT2/D1 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected Cripto-1 on 10 µg of NT2/D1 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information