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05-763 | Anti-Connexin 43 (Cx43) Antibody, α1 subunit

05-763
200 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, Vrt WB, IHC M Culture Supernatant Monoclonal Antibody
      Description
      Catalogue Number05-763
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Connexin 43 (Cx43) Antibody, α1 subunit
      References
      Product Information
      FormatCulture Supernatant
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Applications
      ApplicationAnti-Connexin 43 (Cx43) Antibody, α1 subunit detects level of Connexin 43 (Cx43) & has been published & validated for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Biological Information
      ImmunogenBovine thyroglobulin coupled peptide corresponding to amino acids 131-142 of human Connexin 43
      HostMouse
      SpecificityConnexin 43
      IsotypeIgG
      Species Reactivity
      • Human
      • Rat
      • Vertebrates
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.
      Gene Symbol
      • GJA1
      • Cx43
      • CX43
      • ODD
      • ODOD
      • GJAL
      • DFNB38
      • SDTY3
      • ODDD
      • Connexin-43
      Purification MethodConcentrated culture supernatant
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P17302 # One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.
      SIZE: 382 amino acids; 43008 Da
      SUBUNIT: A connexon is composed of a hexamer of connexins. Interacts with SGSM3.
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
      TISSUE SPECIFICITY: Expressed in the heart and fetal cochlea.
      DISEASE: SwissProt: P17302 # Defects in GJA1 are the cause of autosomal dominant oculodentodigital dysplasia (ODDD) [MIM:164200]; also known as oculodentoosseous dysplasia. ODDD is a highly penetrant syndrome presenting with craniofacial (ocular, nasal, dental) and limb dysmorphisms, spastic paraplegia, and neurodegeneration. Craniofacial anomalies tipically include a thin nose with hypoplastic alae nasi, small anteverted nares, prominent columnella, and microcephaly. Brittle nails and hair abnormalities of hypotrichosis and slow growth are present. Ocular defects include microphthalmia, microcornea, cataracts, glaucoma, and optic atrophy. Syndactyly type III and conductive deafness can occur in some cases. Cardiac abnormalities are observed in rare instances. & Defects in GJA1 may be the cause of syndactyly type III (SDTY3) [MIM:186100]. Syndactyly is an autosomal dominant trait and is the most common congenital anomaly of the hand or foot. It is marked by persistence of the webbing between adjacent digits, so they are more or less completely attached. In this type there is usually complete and bilateral syndactyly between the fourth and fifth fingers. Usually it is soft tissue syndactyly but occasionally the distal phalanges are fused. The fifth finger is short with absent or rudimentary middle phalanx. The feet are not affected. & Defects in GJA1 a the cause of hypoplastic left heart syndrome (HLHS) [MIM:241550]. HLHS refers to the abnormal development of the left-sided cardiac structures, resulting in obstruction to blood flow from the left ventricular outflow tract. In addition, the syndrome includes underdevelopment of the left ventricle, aorta, and aortic arch, as well as mitral atresia or stenosis.
      SIMILARITY: SwissProt: P17302 ## Belongs to the connexin family. Alpha-type (group II) subfamily.
      Molecular Weight~43kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on rat brain microsomal preparations
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Connexin 43 (Cx43), 1 subunit - 26779 26779
      Anti-Connexin 43 (Cx43), alpha;1 subunit - 26779 26779
      Anti-Connexin 43 (Cx43), α1 subunit 2472933

      References

      Reference overviewApplicationPub Med ID
      The significance of pore microarchitecture in a multi-layered elastomeric scaffold for contractile cardiac muscle constructs.
      Hyoungshin Park,Benjamin L Larson,Maxime D Guillemette,Saloni R Jain,Casey Hua,George C Engelmayr,Lisa E Freed
      Biomaterials 32 2011

      Show Abstract
      21144580 21144580
      The connexin43 C-terminal region mediates neuroprotection during stroke.
      Kozoriz MG, Bechberger JF, Bechberger GR, Suen MW, Moreno AP, Maass K, Willecke K, Naus CC
      Journal of neuropathology and experimental neurology 69 196-206 2010

      Show Abstract
      20084014 20084014
      Gap junctions: structure and function (Review).
      Evans, W Howard and Martin, Patricia E M
      Mol. Membr. Biol., 19: 121-36 (2002) 2002

      Show Abstract
      12126230 12126230
      Stage-specific and differential expression of gap junctions in the mouse ovary: connexin-specific roles in follicular regulation.
      Wright, C S, et al.
      Reproduction, 121: 77-88 (2001) 2001

      Show Abstract
      Immunohistochemistry (Tissue)11226030 11226030
      Functional analysis of amino acid sequences in connexin43 involved in intercellular communication through gap junctions.
      Becker, D L, et al.
      J. Cell. Sci., 108 ( Pt 4): 1455-67 (1995) 1995

      7615666 7615666

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies