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07-377 | Anti-Citrulline Antibody

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, Vrt WB, IHC Rb Affinity Purified Polyclonal Antibody
      Catalogue Number07-377
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Citrulline Antibody
      Background InformationThe amino acid Citrulline is required to detoxify the liver from ammonia, which is a waste product of the body from oxidation. Citrulline promotes energy and assists with the immune system. This unusual amino acid is formed in the urea cycle by the addition of carbon dioxide and ammonia to ornithine. It is then combined with aspartic acid to form arginosuccinic acid, which later is metabolized into the amino acid arginine.
      Product Information
      FormatAffinity Purified
      • Human outer cornified layer whole cell lysate
      Presentation25mM Tris/Tris-HCl, pH 7.4, 137mM NaCl,2.7mM KCl, 0.02% sodium azide before the addition of glycerol to 30%
      ApplicationDetect Citrulline with Anti-Citrulline Antibody (Rabbit Polyclonal Antibody), that has been shown to work in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Biological Information
      ImmunogenLinear peptide containing Citrulline.
      SpecificityMultiple deiminated keratins in human cornified skin. Thought to react preferentially with citrulline residues in glycine rich contexts.
      Species Reactivity
      • Human
      • Mouse
      • Vertebrates
      Antibody TypePolyclonal Antibody
      Purification MethodImmunoAffinity Purified
      Molecular Weight43-65 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot in whole cell lysates from tape-stripped human outer cornified layers
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Citrulline - 2424768 2424768
      Anti-Citrulline - 2455634 2455634
      Anti-Citrulline - 2037648 2037648
      Anti-Citrulline - 2106581 2106581
      Anti-Citrulline - 2188671 2188671
      Anti-Citrulline - 2268818 2268818
      Anti-Citrulline - 2299574 2299574
      Anti-Citrulline - 24232 24232
      Anti-Citrulline - DAM1745330 DAM1745330
      Anti-Citrulline - DAM1776459 DAM1776459
      Anti-Citrulline - JBC1924339 JBC1924339
      Anti-Citrulline - NRG1705409 NRG1705409
      Anti-Citrulline -2700831 2700831
      Anti-Citrulline -2776790 2776790


      Reference overviewApplicationPub Med ID
      Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticles in vitro and in vivo.
      Mohamed, BM; Verma, NK; Davies, AM; McGowan, A; Crosbie-Staunton, K; Prina-Mello, A; Kelleher, D; Botting, CH; Causey, CP; Thompson, PR; Pruijn, GJ; Kisin, ER; Tkach, AV; Shvedova, AA; Volkov, Y
      Nanomedicine (London, England) 7 1181-95 2012

      Show Abstract
      Western Blotting22625207 22625207
      Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization.
      Kopp, HG; Hooper, AT; Broekman, MJ; Avecilla, ST; Petit, I; Luo, M; Milde, T; Ramos, CA; Zhang, F; Kopp, T; Bornstein, P; Jin, DK; Marcus, AJ; Rafii, S
      The Journal of clinical investigation 116 3277-91 2006

      Show Abstract Full Text Article
      17143334 17143334
      Sequential reorganization of cornified cell keratin filaments involving filaggrin-mediated compaction and keratin 1 deimination.
      Ishida-Yamamoto, Akemi, et al.
      J. Invest. Dermatol., 118: 282-7 (2002) 2002

      Show Abstract
      11841545 11841545
      Decreased deiminated keratin K1 in psoriatic hyperproliferative epidermis.
      Ishida-Yamamoto, A, et al.
      J. Invest. Dermatol., 114: 701-5 (2000) 2000

      Show Abstract
      10733676 10733676
      Studies on specificity of peptidylarginine deiminase reactions using an immunochemical probe that recognizes an enzymatically deiminated partial sequence of mouse keratin K1.
      Senshu, T, et al.
      J. Dermatol. Sci., 21: 113-26 (1999) 1999

      Show Abstract
      10511480 10511480
      Preferential deimination of keratin K1 and filaggrin during the terminal differentiation of human epidermis.
      Senshu, T, et al.
      Biochem. Biophys. Res. Commun., 225: 712-9 (1996) 1996

      Show Abstract
      8780679 8780679