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ABS445 | Anti-Caspase-5 Antibody

ABS445
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, ICC, IF Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberABS445
      DescriptionAnti-Caspase-5 Antibody
      Alternate Names
      • Caspase-5
      • CASP-5
      • ICE(rel)-III
      • Protease ICH-3
      • Protease TY
      • Caspase-5 subunit p202.Caspase-5 subunit p10
      Background InformationCaspase-5 (CASP5) is a member of the peptidase C14A family that can be divided into the apoptotic and inflammatory caspase subfamilies. Members of this subfamily include caspase-1, -4, -5, and -12. When activated, these caspases result in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18. Caspase-5 is expressed in barely detectable amounts in most tissues except brain, with highest levels being found in lung, liver and skeletal muscle. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Ramos cell lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Applications
      ApplicationDetect Caspase 5 using this rabbit polyclonal antibody, Anti-Caspase-5 Antibody validated for use in western blotting, ICC & Immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunofluorescence
      Application NotesImmunocytochemistry Analysis: 2 µg/mL from a representative lot detected Caspase-5 in P815 cells.

      Immunofluorescence Analysis: 2 µg/mL from a representative lot detected Caspase-5 in P815 cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the intermediate domain of human Caspase-5.
      EpitopeIntermediate domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the intermediate domain of Caspase-5.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • CASP5
      • ICH3
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~48 kDa observed. Uncharacterized bands may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Ramos cell lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected Caspase-5 in Ramos cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications