AB5566 Anti-Capsaicin Receptor Antibody, CT

AB5566
50 µL  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R IHC Gp Serum Polyclonal Antibody
      Description
      Catalogue NumberAB5566
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Capsaicin Receptor Antibody, CT
      Alternate Names
      • Vanilloid Receptor 1
      • VR1
      References
      Product Information
      FormatSerum
      Control
      • Immunogen peptide (catalog number AG298) is available for preadsorbtion control studies.
      PresentationSerum. Liquid. Contains less than 0.02% sodium azide.
      Applications
      ApplicationAnti-Capsaicin Receptor Antibody, C-terminus detects level of Capsaicin Receptor & has been published & validated for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:1,000. The antibody reacts well with tissue from the rat dorsal root ganglia.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenA 22 amino acid peptide corresponding to the C-terminus of the rat Capsaicin Receptor protein (Catalog number AG298).
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostGuinea Pig
      SpecificityRecognizes Capsaicin Receptor (Vanilloid Receptor 1, VR1).
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCapsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
      Gene Symbol
      • TRPV1
      • VR1
      • OTRPC1
      • DKFZp434K0220
      • TrpV1
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q8NER1 # Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL.
      SIZE: 839 amino acids; 94938 Da
      SUBUNIT: Self-associates. Probably homotetramer. May also form a heteromeric channel with TRPV3. Interacts with calmodulin, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
      TISSUE SPECIFICITY: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).DOMAIN:SwissProt: Q8NER1 The association domain (AD) is necessary for self- association (By similarity).
      PTM: Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PKCM and probably PKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity (By similarity).
      SIMILARITY: Belongs to the transient receptor family. TrpV subfamily. & Contains 3 ANK repeats.
      MISCELLANEOUS: Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      GUINEA PIG ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1) POLYCLONAL ANTIBODY - 23877162387716
      GUINEA PIG ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1) POLYCLONAL ANTIBODY - 24333162433316
      GUINEA PIG ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1) POLYCLONAL ANTIBODY - 23428652342865
      GUINEA PIG ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1) - 31748523174852
      GUINEA PIG ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1) POLYCLONAL ANTIBODY3011589
      GUINEA PIG ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1) POLYCLONAL ANTIBODY3135959
      GUINEA PIG ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1) POLYCLONAL ANTIBODY3096504
      GUINEA PIG ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1) POLYCLONAL ANTIBODY2929286
      GUINEA PIG ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1) POLYCLONAL ANTIBODY2941115
      GUINEA PIG ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1) POLYCLONAL ANTIBODY - 20350602035060

      References

      Reference overviewApplicationPub Med ID
      Characterization of bladder sensory neurons in the context of myelination, receptors for pain modulators, and acute responses to bladder inflammation.
      Forrest, SL; Osborne, PB; Keast, JR
      Frontiers in neuroscience  7  206  2013

      Show Abstract
      24223534 24223534
      Transient receptor potential vanilloid type 1 channel (TRPV1) immunolocalization in the murine enteric nervous system is affected by the targeted C-terminal epitope of the applied antibody.
      Buckinx, R; Van Nassauw, L; Avula, LR; Alpaerts, K; Adriaensen, D; Timmermans, JP
      The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society  61  421-32  2013

      Show Abstract
      Immunohistochemistry23482327 23482327
      Enhanced salt sensitivity following shRNA silencing of neuronal TRPV1 in rat spinal cord.
      Yu, SQ; Wang, DH
      Acta pharmacologica Sinica  32  845-52  2011

      Show Abstract
      21642952 21642952
      Intrathecal injection of TRPV1 shRNA leads to increases in blood pressure in rats.
      Yu, SQ; Wang, DH
      Acta physiologica (Oxford, England)  203  139-47  2011

      Show Abstract
      21518266 21518266
      Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2.
      Amadesi S, Grant AD, Cottrell GS, Vaksman N, Poole DP, Rozengurt E, Bunnett NW
      J Comp Neurol  516  141-56  2009

      Show Abstract Full Text Article
      19575452 19575452
      The role of transient receptor potential vanilloid 1 in mechanical and chemical visceral hyperalgesia following experimental colitis.
      A Miranda,E Nordstrom,A Mannem,C Smith,B Banerjee,J N Sengupta
      Neuroscience  148  2007

      Show Abstract Full Text Article
      17719181 17719181
      Activation of vanilloid receptor type I in the endoplasmic reticulum fails to activate store-operated Ca2+ entry
      Wisnoskey, B. J. et al.
      Biochem. J. , 372(Pt 2):517-528 (2003)  2003

      12608892 12608892
      Topography of the vanilloid receptor in the human bladder: more than just the nerve fibers.
      Dieter Ost, Tania Roskams, Frank Van Der Aa, Dirk De Ridder
      The Journal of urology  168  293-7  2002

      Show Abstract
      12050559 12050559
      Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites
      Guo, A. et al.
      Eur. J. Neurosci., 11(3):946-958 (1999)  1999

      10103088 10103088

      Data Sheet

      Title
      Anti-Capsaicin Receptor, C-terminus - Data Sheet

      Related Products & Applications

      Related Products

      Catalog Number Description  
      AB5370 Anti-Capsaicin Receptor Antibody, CT Show Pricing & Availability
      AB5370P Anti-Capsaicin Receptor Antibody, CT Show Pricing & Availability
      AB5889 Anti-Capsaicin Receptor Antibody, NT Show Pricing & Availability
      AB9554 Anti-Capsaicin Receptor Antibody Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies