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ABN549 | Anti-COMT Antibody

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R WB, IHC, ICC Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABN549
      DescriptionAnti-COMT Antibody
      Alternate Names
      • Catechol O-methyltransferase
      • COMT
      Background InformationCatechol O-methyltransferase (COMT) catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. COMT also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. COMT is expressed in brain, liver, placenta, lymphocytes and erythrocytes. COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson's disease.
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide and 40% glycerol.
      ApplicationThis Anti-COMT Antibody is validated for use in Western Blotting
      , Immunohistochemistry
      and Immunocytochemistry for the detection of COMT.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunocytochemistry
      Application NotesImmunohistochemistry Analysis (IHC): A 1:50-200 dilution from a representative lot detected COMT in urinary bladder, cerebral cortex, brain and glioma tissues.

      Immunocytochemistry Analysis (ICC): 1:50-200 dilution from a representative lot detected COMT in U2OS cells.

      Biological Information
      ImmunogenRecombinant protein corresponding to human COMT.
      ConcentrationPlease refer to lot specific datasheet.
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • COMT
      Purification MethodAffinity
      UniProt Number
      Molecular Weight~25 and ~28 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in RT-4 and NBT-II cell lysates.

      Western Blotting Analysis (WB): A 1:100-500 dilution of this antibody detected COMT in RT-4 and NBT-II cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies