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MAB5410 | Anti-CDK5 Antibody

100 µL  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R ICC, IHC, WB M Ascites Monoclonal Antibody
      Catalogue NumberMAB5410
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CDK5 Antibody
      Alternate Names
      • CDK5
      Product Information
      • Positive controls: cerebral cortex and neuronal cell bodies. Neuronal perikarya stain strongly.

        Negative controls: liver and kidney.
      PresentationAscites. Liquid.
      ApplicationAnti-CDK5 Antibody is a Mouse Monoclonal Antibody for detection of Cyclin-dependent Kinase 5 also known as Cyclin-dependent Kinase 5 & has been validated in ICC, IHC & WB.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot: 1:500. The antibody recognizes a protein of ~34 kDa. Suggested blocking buffer is PBS containing 1% non-fat milk.

      Immunohistochemistry on 3.7% formalin or 4% paraformaldehyde fixed frozen tissue. Suggested blocking buffer is PBS with 1% normal goat serum.

      Immunocytochemistry: 1:100. Suggested permeabilization method is -20°C methanol or 0.1% triton X-100 if required. Suggested blocking buffer is PBS with 1% normal goat serum.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenFull length recombinant rat CDK5.
      SpecificityReacts with CDK5 (Neuronal CDC-2 like kinase, NCLK).
      Species Reactivity
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CDK5
      • PSSALRE
      • EC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q00535 # Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase.
      SIZE: 292 amino acids; 33304 Da
      SUBUNIT: Heterodimer of a catalytic subunit and a regulatory subunit (p35). Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1 (By similarity). Interacts with AATK.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, growth cone (By similarity). Note=In axonal growth cone with extension to the peripheral lamellipodia (By similarity).
      SIMILARITY: SwissProt: Q00535 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

      Important Note: During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 


      Reference overviewPub Med ID
      Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.
      Inoue, K; Rispoli, J; Kaphzan, H; Klann, E; Chen, EI; Kim, J; Komatsu, M; Abeliovich, A
      Molecular neurodegeneration 7 48 2012

      Show Abstract
      22998728 22998728

      Data Sheet

      Anti-Cyclin-dependent Kinase 5 - Data Sheet

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      Life Science Research > Antibodies and Assays > Primary Antibodies