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ABT180 | Anti-CDCP1 Antibody

ABT180
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IH(P) Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberABT180
      DescriptionAnti-CDCP1 Antibody
      Alternate Names
      • CUB domain-containing protein 1
      • Membrane glycoprotein gp140
      • Subtractive immunization M plus HEp3-associated 135 kDa protein
      • SIMA135
      • Transmembrane and associated with src kinases
      • CD318
      Background InformationCUB domain-containing protein 1 (CDCP1) is also called Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135 kDa protein (SIMA135), Transmembrane and associated with src kinases and CD_antigen 318. CDCP1 is part of the tetraspanin web involved in tumor progression and metastasis. CDCP1 may also be involved in cell adhesion, cell matrix association and regulation of anchorage versus migration or proliferation versus differentiation via phosphorylation status. CDCP1 is a possible marker for leukemia diagnosis, and for subsets of immature hematopoietic stem cell. CDCP1 is highly expressed in mitotic cells, skeletal muscle, colon, many human tumor cell lines, colorectal cancer, breast carcinoma and lung cancer. CDCP1 may also be found in cells phenotypically similar to mesenchymal stem cells and neural stem cells.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human pancreas tumor tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-CDCP1 Antibody is a highly specific rabbit polyclonal antibody, that targets CUB domain-containing protein 1 & has been tested in western blotting & IHC (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern Blotting Analysis: 2 µg/mL of this antibody detected CDCP1 in a panel of human tumor tissue lysates.

      Immunohistochemistry Analysis: A 1:100 and a 1:500 dilution from a representative lot detected CDCP1 in human breast carcinoma sections.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the cytoplasmic domain of human CDCP1.
      EpitopeCytoplasmic domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the cytoplasmic domain of CDCP1.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with Human. Other Homologies: Mouse and Rat (77% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CDCP1
      • TRASK
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~135 kDa and ~70 kDa observed. Uniprot describes 3 isoforms at 92 kDa, 72 kDa, and 38 kDa, due to alternative splicing. The full length and cleaved form of CDCP1 have been observed at ~135 kDa and ~70 kDa (Casar, B., et al. (2012). Oncogene 31(35):3924-3938.). Uncharacterized band(s) may be observed in some cell lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human pancreas tumor tissue lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected CDCP1 in 10 µg of human pancreas tumor tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications