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CBL582 | Anti-CD19 Antibody, clone HD37

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC, IP, IHC M Purified Monoclonal Antibody
      Catalogue NumberCBL582
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CD19 Antibody, clone HD37
      Alternate Names
      • B-lymphocyte Surface Antigen B4
      Product Information
      PresentationThe monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      ApplicationAnti-CD19 Antibody, clone HD37 detects level of CD19 & has been published & validated for use in FC, IP, IH.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Immunohistochemistry
      Application NotesIdentification of CD19 positive B lymphocytes and malignant B cells by indirect immunofluorescence staining

      Leukaemia and lymphoma phenotyping

      Identification of normal and malignant CD19 positive B lymphocytes in cryostat frozen sections

      Immunoprecipitation of the CD19 antigen

      Studies of the CD19/21 complex in B cell activation and the control of B cell development

      Optimal working dilutions must be determined by the end user.
      Biological Information
      SpecificityThe CD19 antigen (90 kDa) is expressed from the earliest stages of B-progenitor development, on all peripheral B cells including germinal centre B cells and all B cell lines and B cell leukaemias tested. T cell and monocytic cell lines are negative and the antigen is lost on B cell maturations to plasma cells. The antigen is a type I integral membrane glycoprotein whose in vitro inhibition will influence B cell activation and proliferation.
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryLymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
      Gene Symbol
      • CD19
      • B4
      • MGC12802
      • Leu-12
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P15391 # Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
      SIZE: 556 amino acids; 61128 Da
      SUBUNIT: Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
      DISEASE:SwissProt: P15391 # Defects in CD19 are a cause of hypogammaglobulinemia [MIM:107265].
      SIMILARITY: SwissProt: P15391 ## Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-CD19, clone HD37 2472912
      Anti-CD19, clone HD37 - 2127786 2127786
      Anti-CD19, clone HD37 - 2136610 2136610
      Anti-CD19, clone HD37 - 2446755 2446755
      Anti-CD19, clone HD37 - 2111384 2111384
      Anti-CD19, clone HD37 - 2188476 2188476
      Anti-CD19, clone HD37 - 2208771 2208771
      Anti-CD19, clone HD37 - 2225153 2225153
      Anti-CD19, clone HD37 - 2283376 2283376
      Anti-CD19, clone HD37 - LV1731966 LV1731966
      Anti-CD19, clone HD37 -2503011 2503011
      Anti-CD19, clone HD37 -2685532 2685532
      Anti-CD19, clone HD37 -2700209 2700209
      Anti-CD19, clone HD37 -2719887 2719887
      Anti-CD19, clone HD37 -2726739 2726739
      Anti-CD19, clone HD37 -2779127 2779127


      Reference overviewPub Med ID
      Signal transduction in lymphocytic and myeloid cells via CD24, a new member of phosphoinositol-anchored membrane molecules.
      Fischer, G F, et al.
      J. Immunol., 144: 638-41 (1990) 1990

      Show Abstract
      2153173 2153173

      Data Sheet

      Anti-CD19, clone HD37 - Data Sheet

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      Life Science Research > Antibodies and Assays > Primary Antibodies