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MABF545 | Anti-CD152 (CTLA-4) Antibody (mouse), APC, clone UC10-4F10-11

25 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M FC AHm APC Monoclonal Antibody
      Catalogue NumberMABF545
      DescriptionAnti-CD152 (CTLA-4) Antibody (mouse), APC, clone UC10-4F10-11
      Alternate Names
      • Cytotoxic T-lymphocyte protein 4
      • Cytotoxic T-lymphocyte-associated antigen 4
      • CTLA-4
      • CD152
      Background InformationThe UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.
      Product Information
      PresentationPurified Armenian Hamster Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
      ApplicationThis armenian hamster monoclonal antibody Anti-CD152 (CTLA-4) (mouse), APC & clone UC10-4F10-11 validated for use in Flow Cytometry for the detection of CD152 (CTLA-4).
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenImmunogen information for this antibody is proprietary information.
      Concentration0.2 mg/mL
      HostArmenian Hamster
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • Ctla4
      • Cd152
      Purification MethodSize Exclusion Chromatography
      UniProt Number
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceThe monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

      Flow Cytometry Analysis: 0.06 μg of this antibody detected CD152 (CTLA-4) in one million C57Bl/6 splenocytes.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsIt is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
      Packaging Information
      Material Size25 µg
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies