MABF513 | Anti-CD11b Antibody (human/mouse), Biotin, clone M1/70

MABF513
25 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M IP, IHC, FC, IF R Biotin Monoclonal Antibody
      Description
      Catalogue NumberMABF513
      DescriptionAnti-CD11b Antibody (human/mouse), Biotin, clone M1/70
      Alternate Names
      • Integrin alpha-M
      • CD11 antigen-like family member B
      • CR-3 alpha chain
      • Cell surface glycoprotein MAC-1 subunit alpha
      • Leukocyte adhesion receptor MO1
      • Neutrophil adherence receptor
      • CD antigen CD11b
      Background InformationThe M1/70 antibody reacts with human and mouse CD11b, also known as integrin alpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha M (CD11b) assembles with Integrin beta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling throµgh ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The M1/70 antibody is widely used as a marker for CD11b expression on mouse macrophages, granulocytes, neutrophils, and NK cells. The antibody is also reported to be cross-reactive for Rhesus macaque CD11b.
      References
      Product Information
      FormatBiotin
      PresentationPurified Rat Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
      Applications
      ApplicationThis rat monoclonal antibody Anti-CD11b (human/mouse), Biotin, clone M1/70 validated for use in IP, IHC, Flow Cytometry & Immunofluorescence for the detection of CD11b.
      Key Applications
      • Immunoprecipitation
      • Immunohistochemistry
      • Flow Cytometry
      • Immunofluorescence
      Biological Information
      ImmunogenImmunogen information for this antibody is proprietary information.
      CloneM1/70
      Concentration0.5 mg/mL
      HostRat
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • ITGAM
      • CD11B
      • CR3A
      Purification MethodSize Exclusion Chromatography
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceThe monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

      Flow Cytometry Analysis: 0.125 µg of this antibody detected CD11b in one million C57Bl/6 bone marrow cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsIt is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
      Packaging Information
      Material Size25 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies