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CBL1360 | Anti-CD117 Antibody, clone ACK2

500 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M FC, IHC, IP, FUNC, WB R Purified Monoclonal Antibody
      Catalogue NumberCBL1360
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CD117 Antibody, clone ACK2
      Alternate Names
      • c-kit
      • SCF Receptor
      Background InformationThis 145 kDa molecule is a member of the tyrosine kinase receptor family and is expressed by a majority of hematopoietic progenitor cells. The interaction of the mouse c-kit receptor and steel factor promotes proliferation and differentiation of hematopoietic progenitor cells. CD117 is also expressed by mast cells, and plays a role in signaling and activation of these cells.
      Product Information
      • Skin tissue, normal breast epithelium, melanocytes, mast cells and glial cells
      PresentationThe monoclonal is presented in phosphate buffered saline containing 10mM sodium azide.
      ApplicationDetect CD117 using this Anti-CD117 Antibody, clone ACK2 validated for use in FC, IH, IP, FUNC & WB.
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry
      • Immunoprecipitation
      • Affects Function
      • Western Blotting
      Application NotesFlow Cytometry: 0.2 μg per 10e6 cells


      Immunohistochemistry (Frozen)

      Western blot

      Blocking Ligand Binding

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificitySpecifically recognizes mouse CD117, known as c-kit receptor, stem cell factor receptor and steel factor receptor.
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • KIT
      • CD117
      • SCFR
      • C-Kit
      • PBT
      • c-kit
      • EC
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P10721 # This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K).
      SIZE: 976 amino acids; 109865 Da
      SUBUNIT: Interacts with APS. Interacts with the tenth PDZ domain of MPDZ.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DISEASE: SwissProt: P10721 # Defects in KIT are a cause of piebaldism [MIM:172800]. Piebaldism is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes. & Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764]. & Defects in KIT have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).
      SIMILARITY: SwissProt: P10721 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
      Stem Cell Type
      • Hematopoietic Stem Cells
      • Mesenchymal Stem Cells
      Molecular Weight145 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
      Packaging Information
      Material Size500 µg
      Transport Information
      Supplemental Information


      Certificates of Analysis

      TitleLot Number
      RAT ANTI-MOUSE CD117 MONOCLONAL ANTIBODY - 2383956 2383956
      RAT ANTI-MOUSE CD117 MONOCLONAL ANTIBODY - 2219326 2219326


      Reference overviewPub Med ID
      Using a new Lrig1 reporter mouse to assess differences between two Lrig1 antibodies in the intestine.
      Poulin, EJ; Powell, AE; Wang, Y; Li, Y; Franklin, JL; Coffey, RJ
      Stem cell research 13 422-30 2014

      Show Abstract
      25460603 25460603
      CDH1 is a specific marker for undifferentiated spermatogonia in mouse testes.
      Tokuda, M; Kadokawa, Y; Kurahashi, H; Marunouchi, T
      Biology of reproduction 76 130-41 2007

      Show Abstract
      17035642 17035642
      Stage-specific expression of the Kit receptor and its ligand (KL) during male gametogenesis in the mouse: a Kit-KL interaction critical for meiosis.
      Vincent, S, et al.
      Development, 125: 4585-93 (1998) 1998

      Show Abstract
      9778516 9778516

      Data Sheet

      Anti-CD117, clone ACK2 - Data Sheet

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      Life Science Research > Antibodies and Assays > Primary Antibodies