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06-994 | Anti-CAP (c-Cbl associated protein) Antibody

200 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB Rb Purified Polyclonal Antibody
      Catalogue Number06-994
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-CAP (c-Cbl associated protein) Antibody
      Product Information
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      ApplicationAnti-CAP (c-Cbl associated protein) Antibody detects level of CAP (c-Cbl associated protein) & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide corresponding to amino acids 192-206 (CEKRAKDDSRRVVKST) of human CAP (c-Cbl associated protein), also known as ponsin
      SpecificityCAP and two other isoforms or alternatively spliced variants at 125 and 53kDa; other splice variants that may be detected are at 75kDa and 45kDa
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SORBS1
      • SH3P12
      • DKFZp586P1422
      • DKFZP586P1422
      • DKFZp451C066
      • KIAA1296
      • Ponsin
      • SH3D5
      • FLAF2
      • sh3p12
      • SORB1
      • ponsin
      • R85FL
      • FLJ12406
      • CAP
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9BX66 # Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).
      SIZE: 1292 amino acids; 142455 Da
      SUBUNIT: Interacts with the long isoform of MLLT4/afadin and with VCL. MLLT4 and VCL bind to SORBS1 in a competitive manner and do not form a ternary complex. Interacts with ABL1, CBL, CBLB and INPPL1/SHIP2 through the third SH3 domain. Interaction with ABL1 occurs only after insulin stimulation while this has no effect on the interaction with INPPL1. Interacts with the insulin receptor but dissociates from it following insulin stimulation. Also interacts with SCA7, PTK2/p125FAK and flotillin.
      SUBCELLULAR LOCATION: Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Note=Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions.TISSUE SPECIFICITY: Widely expressed with highest levels in heart and skeletal muscle.
      PTM: O-glycosylated (By similarity).
      SIMILARITY: SwissProt: Q9BX66 ## Contains 3 SH3 domains. & Contains 1 SoHo domain.
      Molecular Weight99kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on a RIPA lysate prepared from a 3T3-L1 adipocytes
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-CAP (c-Cbl associated protein) - 19419 19419
      Anti-CAP (c-Cbl associated protein) - 23849 23849


      Reference overviewPub Med ID
      A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes.
      Ribon, V, et al.
      Mol. Cell. Biol., 18: 872-9 (1998) 1998

      Show Abstract
      9447983 9447983
      A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions.
      Ribon, V, et al.
      J. Biol. Chem., 273: 4073-80 (1998) 1998

      Show Abstract
      9461600 9461600