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AB1892 | Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, NT

AB1892
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R IHC, WB Rb Purified Polyclonal Antibody
      Description
      Catalogue NumberAB1892
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-C-X-X-X-C Chemokine Receptor 1 Antibody, NT
      Alternate Names
      • CX3CR1
      Background InformationCX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively (1-4). The seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1 (5). Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by facktokine (6). CX3CR1 mediates leukocyte migration and adhesion.
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. 100 μg purified IgG in 100 μL of PBS containing 0.2% sodium azide.
      Applications
      ApplicationDetect C-X-X-X-C Chemokine Receptor 1 using this Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, N-terminus validated for use in IH & WB.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot: 1:500 - 1:2000 (Human spleen tissue lysate can be used as positive control and an approximately 50 kDa band can be detected)

      Immunohistochemistry in frozen sections

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide from the N-terminal of human CX3CR1.
      EpitopeN-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificitySpecific for human C-X-X-X-C Chemokine Receptor 1 (CX3CR1) at the Extracellular loop. The sequence is identical to that of rat and differs from that of mouse by only one amino acid.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CX3CR1
      • CMKDR1
      • GPR13
      • CMK-BRL-1
      • V28
      • GPRV28
      • CMKBRL1
      • CCRL1
      • CMKBLR1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P49238 # Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV coreceptors than isoform 1.
      SIZE: 355 amino acids; 40396 Da
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Expressed in lymphoid and neural tissues.
      SIMILARITY: SwissProt: P49238 ## Belongs to the G-protein coupled receptor 1 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at 2-8°C for up to 12 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI- CHEMOKINE RECEPTOR CX3CR1 N-TERMINAL -2668081 2668081
      RABBIT ANTI- CHEMOKINE RECEPTOR CX3CR1 N-TERMINAL -2788188 2788188
      RABBIT ANTI- CHEMOKINE RECEPTOR CX3CR1 N-TERMINAL POLYCLONAL ANTIBODY - 2271127 2271127

      References

      Reference overviewPub Med ID
      Spatial and temporally restricted expression of chemokines and chemokine receptors in the developing human kidney.
      Hermann-Josef Gröne, Clemens D Cohen, Elisabeth Gröne, Claudia Schmidt, Matthias Kretzler, Detlef Schlöndorff, Peter J Nelson
      Journal of the American Society of Nephrology : JASN 13 957-67 2002

      Show Abstract
      11912255 11912255
      Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion.
      Imai, T, et al.
      Cell, 91: 521-30 (1997) 1997

      Show Abstract
      9390561 9390561
      The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues.
      Raport, C J, et al.
      Gene, 163: 295-9 (1995) 1995

      Show Abstract
      7590284 7590284
      Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene.
      Combadiere, C, et al.
      DNA Cell Biol., 14: 673-80 (1995) 1995

      Show Abstract
      7646814 7646814
      cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors.
      Harrison, J K, et al.
      Neurosci. Lett., 169: 85-9 (1994) 1994

      Show Abstract
      8047298 8047298

      Data Sheet

      Title
      Anti-C-X-X-X-C Chemokine Receptor 1, N-terminus - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies