A part of MilliporeSigma

AB1847 | Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop

100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
Request Pricing
Limited AvailabilityLimited Availability
Limited Quantities Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers


      Contact Customer Service

      Click To Print This Page


      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB Rb Purified Polyclonal Antibody
      Catalogue NumberAB1847
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop
      Alternate Names
      • CD184
      • CXCR4
      Product Information
      PresentationPurified IgG in PBS containing 0.02% sodium azide.
      ApplicationAnti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop detects level of C-X-C Chemokine Receptor 4 & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:500 - 1000

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenExtracellular loop peptide of human CXCR4 (Berson et al. 1996; Leotscher et al. 1994).
      Epitopeextracellular loop
      SpecificitySome G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors (Nimitrov 1997). Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principle coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells (Feng et al. 1996; Berson et al. 1996). CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2 (Doranz et al. 1996; Endres et al. 1996). The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1 (Bleul et al. 1996; Oberlin et al. 1996). CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells (Lapham et al. 1996). CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types (Feng et al. 1996). Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells (Feng et al. 1996; Endres et al. 1996; Brelot et al. 1997). The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites (Brelot et al. 1997; Lu et al. 1997).
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
      Gene Symbol
      • CXCR4
      • WHIM
      • NPY3R
      • NPYY3R
      • FB22
      • LAP3
      • Fusin
      • CXCR-4
      • LCR1
      • NPYR
      • HM89
      • fusin
      • HSY3RR
      • CXC-R4
      • NPYY3
      • NPYRL
      • D2S201E
      • CD184
      • LESTR
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P61073 # Receptor for the C-X-C chemokine CXCL12/SDF-1. Transduces a signal by increasing the intracellular calcium ions level. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.
      SIZE: 352 amino acids; 39746 Da
      SUBUNIT: Interacts with HIV-1 surface protein gp120 and Tat.
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.
      DOMAIN: SwissProt: P61073 The amino-terminus is critical for ligand binding. Residues in all four extracellular regions contribute to HIV-1 coreceptor activity.
      PTM: Sulfated.
      DISEASE: SwissProt: P61073 # Defects in CXCR4 are a cause of WHIM syndrome [MIM:193670]; also called warts, hypogammaglobulinemia, infections, and myelokathexis. WHIM syndrome is an immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despite the peripheral neutropenia, bone marrow aspirates from affected individuals contain abundant mature myeloid cells, a condition termed myelokathexis.
      SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsCan be refrigerated at 2-8°C in undiluted aliquots for up to 12 months from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number

      References | 15 Available | See All References

      Reference overviewPub Med ID
      CXCR4 attenuates cardiomyocytes mitochondrial dysfunction to resist ischaemia-reperfusion injury.
      Cai, WF; Kang, K; Huang, W; Liang, JL; Feng, YL; Liu, GS; Chang, DH; Wen, ZL; Paul, C; Xu, M; Millard, RW; Wang, Y
      Journal of cellular and molecular medicine 19 1825-35 2015

      Show Abstract
      25824297 25824297
      Akt/hypoxia-inducible factor-1α signaling deficiency compromises skin wound healing in a type 1 diabetes mouse model.
      Jing, L; Li, S; Li, Q
      Experimental and therapeutic medicine 9 2141-2146 2015

      Show Abstract
      26136949 26136949
      Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells.
      Zeniou, M; Fève, M; Mameri, S; Dong, J; Salomé, C; Chen, W; El-Habr, EA; Bousson, F; Sy, M; Obszynski, J; Boh, A; Villa, P; Assad Kahn, S; Didier, B; Bagnard, D; Junier, MP; Chneiweiss, H; Haiech, J; Hibert, M; Kilhoffer, MC
      PloS one 10 e0134793 2015

      Show Abstract
      26270679 26270679
      Effects of progesterone on the content of CCR5 and CXCR4 coreceptors in PBMCs of seropositive and exposed but uninfected Mexican women to HIV-1.
      Edith Cabrera-Muñoz,Luis L Fuentes-Romero,Jorge Zamora-Chávez,Ignacio Camacho-Arroyo,Luis E Soto-Ramírez
      The Journal of steroid biochemistry and molecular biology 132 2012

      Show Abstract
      22342838 22342838
      CD24 affects CXCR4 function in pre-B lymphocytes and breast carcinoma cells.
      Schabath, H; Runz, S; Joumaa, S; Altevogt, P
      Journal of cell science 119 314-25 2006

      Show Abstract
      16390867 16390867
      Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity.
      Brelot, A, et al.
      J. Virol., 71: 4744-51 (1997) 1997

      Show Abstract
      9151868 9151868
      Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains.
      Lu, Z, et al.
      Proc. Natl. Acad. Sci. U.S.A., 94: 6426-31 (1997) 1997

      Show Abstract
      9177234 9177234
      How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity.
      Dimitrov, D S
      Cell, 91: 721-30 (1997) 1997

      9413981 9413981
      HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor.
      Feng, Y, et al.
      Science, 272: 872-7 (1996) 1996

      Show Abstract
      8629022 8629022
      A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.
      Doranz, B J, et al.
      Cell, 85: 1149-58 (1996) 1996

      Show Abstract
      8674120 8674120


      Human Stem Cell Systems

      Data Sheet


      Related Products & Applications

      Related Products

      Catalog Number Description  
      AB1846 Anti-C-X-C Chemokine Receptor 4 Antibody, NT Show Pricing & Availability
      AB4251 Anti-CXC Chemokine Receptor 4 Antibody, NT, extracellular Show Pricing & Availability
      MABF981 Anti-CXCR4 Antibody, clone 12G5 Show Pricing & Availability

      Product Families

      View Gene Related Products for this Target


      Life Science Research > Antibodies and Assays > Primary Antibodies