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ABS158 | Anti-BubR1 Antibody

100 µg  
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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABS158
      DescriptionAnti-BubR1 Antibody
      Alternate Names
      • Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
      • MAD3/BUB1-related protein kinase
      • hBUBR1
      • Mitotic checkpoint kinase MAD3L
      • Protein SSK1
      Background InformationThe mitotic checkpoint prevents the resulting two daughter cells from having unequal numbers of chromosomes. This condition, known as aneuploidy, is present in almost all cancer cells and may be due to malfunctions in the mitotic checkpoint. BubR1 is a mitotic checkpoint kinase and has been implicated in the metaphase checkpoint control in mammalian cells.
      Product Information
      FormatAffinity Purified
      • HEK293 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-BubR1 is an antibody targeting the BubR1 protein, validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: A representative lot detected BubR1 in HeLa, A431, HepG2, and NIH/3T3 cell lysates.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to N-terminus of human BubR1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes the N-terminus of BubR1.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteDemonstrated to react with Human and Mouse. Other homologies: Bovine (93% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • BubR1
      • BUBR1
      • MAD3L
      • SSK1
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~120 kDa observed. Uncharacterized bands were observed at ~45 kDa, ~100 kDa, ~160 kDa in some cell lysates.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HEK293 cell lysate.

      Western Blotting Analysis: 2 μg/mL of this antibody detected BubR1 in 10 μg of HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies