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AB15417 | Anti-Beclin 1 Antibody

AB15417
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, ICC, IHC Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB15417
      ReplacesMABN16
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Beclin 1 Antibody
      Alternate Names
      • Coiled-coil myosin-like BCL2-interacting protein
      • BECN1
      Background InformationAutophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. Beclin 1 is a BCL-2 interacting protein and this protein was shown to play a role in the promotion of autophagy.
      References
      Product Information
      FormatSerum
      PresentationLyophilized. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative.
      Applications
      ApplicationDetect Beclin 1 using this Anti-Beclin 1 Antibody validated for use in WB, IC, IH.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesWestern blot: 1:100-1:2,000
      Immunocytochemistry: 1:100-1:2,000
      Immunohistochemistry: 1:100-1:2,000
      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to the C-terminus of human Beclin 1 protein.
      HostRabbit
      SpecificityBeclin 1 [Coiled-coil myosin-like BCL2-interacting protein, BECN1].
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • BECN1
      • GT197
      • Beclin-1
      • beclin1
      • ATG6
      • VPS30
      Purification MethodSerum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q14457 # May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. May play a role in autophagy.
      SIZE: 450 amino acids; 51896 Da
      SUBUNIT: Interacts with GOPC and GRID2 (By similarity). Interacts with BCL2 and BCL2L1.
      SUBCELLULAR LOCATION: Cytoplasm (Potential). Golgi apparatus membrane; Peripheral membrane protein (By similarity). Note=Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity).
      TISSUE SPECIFICITY: Ubiquitous.
      SIMILARITY: SwissProt: Q14457 ## Belongs to the beclin family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material frozen at -20°C to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-BECLIN 1 POLYCLONAL ANTIBODY - 2151824 2151824
      RABBIT ANTI-BECLIN 1 POLYCLONAL ANTIBODY - 2428471 2428471
      RABBIT ANTI-BECLIN 1 -2519323 2519323
      RABBIT ANTI-BECLIN 1 -2739508 2739508
      RABBIT ANTI-BECLIN 1 -2816871 2816871
      RABBIT ANTI-BECLIN 1 POLYCLONAL ANTIBODY - 2006042 2006042
      RABBIT ANTI-BECLIN 1 POLYCLONAL ANTIBODY - 2205906 2205906

      References

      Reference overviewPub Med ID
      Neurodegeneration induces upregulation of Beclin 1.
      Erlich, Shlomit, et al.
      Autophagy, 2: 49-51 (2006) 2006

      Show Abstract
      16874043 16874043
      Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation.
      Iwata, Atsushi, et al.
      Proc. Natl. Acad. Sci. U.S.A., 102: 13135-40 (2005) 2005

      Show Abstract
      16141322 16141322

      Brochure

      Title
      Advancing cancer research: From hallmarks & biomarkers to tumor microenvironment progression
      Autophagy Solutions - Novel antibodies, inhibitors and innovative assays

      Data Sheet

      Title
      RABBIT ANTI-BECLIN 1 POLYCLONAL ANTIBODY - Data Sheet

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      Product Families

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies