A part of MilliporeSigma

ABC406 | Anti-BCL2L10 Antibody

150 µL  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberABC406
      DescriptionAnti-BCL2L10 Antibody
      Alternate Names
      • Bcl-2-like protein 10
      • Bcl2-L-10
      • Anti-apoptotic protein NrH
      • Apoptosis regulator Bcl-B
      • BCL2L10
      Background InformationThe protein named Bcl-2-like protein 10 (Bcl2-L-10) or alternatively Anti-apoptotic protein NrH or Apoptosis regulator Bcl-B, and encoded by the human gene BCL2L10/BCLB is member of the BcL2 anti-apoptosis family and promotes cell survival by suppressing the actions of BAX and BAK in destabilizing the mitochondrial membrane potential leading to apoptosis activation. BCL2L10 can interact with Bcl-2, BcL2L1/BCL-XL, and BAX. It is expressed in the cytoplasm and interacts primarily at the mitochondrial membranes. BCL2L10 is abundantly expressed in human embryos prior to implantation and was predominantly cytoplasmic with localization at the mitochondria in normal embryos. In abnormal embryos BCL2L10 was outside the mitochondria as well as nuclear located, but the exact nature of the role of BCL2L10 in abnormal embryos is still be elucidated. Interestingly, BCL2L10 because of its anti-apoptotic effects is also the cause for anti-cancer drug resistance and it is used a marker for potential drug failures in anti-cancer therapy. EMD-Millipore’s Anti-BCL2L10 rabbit polyclonal antibody has been tested in western blots on A2780 cell extracts and in paraffin embedded immunohistochemistry on human lung tissue sections.
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide and 50% glycerol.
      ApplicationAnti-BCL2L10 antibody detects level of BCL2L10 & has been published & validated for use in BCL2L10.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected BCL2L10 in human lung tissue.
      Biological Information
      ImmunogenGST-tagged fusion protein corresponding to human BCL2L10.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • BCL2L10
      • BCLB
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~22 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in A2780 cell lysate.

      Western Blotting Analysis: A 1:300 dilution of this antibody detected BCL2L10 in A2780 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size150 µL
      Transport Information
      Supplemental Information

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      Life Science Research > Antibodies and Assays > Primary Antibodies